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\begin{document}

\title{Microcirculation measurements in the skin and retina: review of
non-invasive tools and their challenges}



\author[1]{Willem Birkhoff}%
\author[2]{Sebastiaan Kraaij}%
\author[2]{Matthijs Moerland}%
\author[2]{Karen Broekhuizen}%
\author[2]{Adam Cohen (EMA-commentaries only)}%
\author[3]{Pim Gal}%
\affil[1]{Leiden Universitair Medisch Centrum}%
\affil[2]{Centre for Human Drug Research}%
\affil[3]{Affiliation not available}%


\vspace{-1em}



  
  \date{May 28, 2024}


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\begin{abstract}
In the last decade new and more advanced microvascular imaging
techniques have become available for use in clinical research. As it
became more evident that microvascular dysfunction might prelude
(cardio) vascular events, microvascular measurements have gained
increasing interest for their applicability in the clinic and research.
In this narrative review we aim to provide an updated oversight of
microvascular measurement techniques. We have made an outline of the
most common and latest techniques for microvascular cutaneous and
retinal measurements and included the most frequently used challenges
used together with these measurements. Furthermore this review includes
an updated evaluation of the mechanistic background of microcirculatory
dysfunction. Hereby this narrative literature review aims to assist with
the identification of the most adequate microvascular imaging
technique(s) for clinical application and research%
\end{abstract}%



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\textbf{Hosted file}

\verb`MICROC~4.DOC`  available at \url{https://authorea.com/users/495420/articles/577158-microcirculation-measurements-in-the-skin-and-retina-review-of-non-invasive-tools-and-their-challenges}

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\end{document}

