Acknowledgements Supported by grants from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 835286) (PG).Conflicts of interest FDL, PG, and RN are the founding scientists of FloNext Srl. PG has been in advisory boards and/or received fees for lectures from Novartis, Amgen, TEVA, AbbVie, Eli-Lilly, Lundbeck. The other authors have no conflicts of interest to declare.Author contributionsFDL, PG, RN conceived the project, analyzed the data, and wrote the manuscript; GDS, LL, MM, DSMdA, AR, LFI performed the experiments and analyzed the data.Data availability statementThe data that support the findings of this study are available from the corresponding author upon reasonable request.Ethics approval statementStudy on animals was approved by the Italian Ministry of Health (research permit 360/2022-PR).