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\begin{document}

\title{A Phase I, Single-sequence, Open-label Study to Evaluate the Drug-Drug
Interaction Between Hetrombopag and Cyclosporine in Healthy Chinese
Subjects.}



\author[1]{Fengshan Li}%
\author[2]{Hongda Lin}%
\author[1]{Qin Yu}%
\author[2]{Kai Shen}%
\author[1]{Lingli Zhang}%
\author[2]{Sheng Feng}%
\author[2]{Yiwen Wu}%
\author[1]{Shiyin Feng}%
\author[1]{Xiaohong Liu}%
\author[3]{Linrui Cai}%
\author[3]{Zhuo Chen}%
\author[3]{Qin Zou}%
\author[3]{Xu Su}%
\affil[1]{Sichuan University West China Second University Hospital}%
\affil[2]{Jiangsu Hengrui Medicine Co Ltd}%
\affil[3]{West China Women's and Children's Hospital}%


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  \date{May 17, 2024}


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\begin{abstract}
Aims: This study aims to evaluate the drug-drug interaction(DDI)
between hetrombopag and cyclosporine in healthy Chinese subjects.
Methods: Twenty-six eligible subjects enrolled in this single-center,
single-sequence, open-label, DDI study with three treatment periods,
receiving 5 mg hetrombopag once on day 1, 100 mg cyclosporine twice
daily from day 11 to day 15, and 5 mg hetrombopag + 100 mg cyclosporine
on day 16. Serial blood samples were collected for pharmacokinetic
evaluation. Adverse events were monitored throughout the study. Results:
The plasma hetrombopag geometric mean ratios (GMRs) (90\% CI) of Cmax,
AUC0-t and AUC0-[?] of co-administration of hetrombopag with cyclosporine
vs hetrombopag alone are 95.97\% (70.08\%, 131.43\%), 105.75\% (75.04\%,
149.04\%) and 104.19\% (74.71\%, 145.32\%), respectively, indicating
multiple doses of cyclosporine had minimal effects on hetrombopag
exposure. The GMRs (90\% CI) of Cmax and AUCss,tau for blood
cyclosporine of co-administration vs cyclosporine alone were 100.49\%
(91.89\%, 109.89\%) and 100.81\% (107.88\%, 103.82\%), respectively,
suggesting a single dose of hetormbopag had no impact on the exposure of
cyclosporine. Co-administration of hetormbopag with cyclosporine was
generally well tolerated. Conclusion: No clinically significant DDI was
observed when co-administration of hetrombopag with cyclosporine. No
additional dose adjustment is warranted for this combination.%
\end{abstract}%



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\textbf{Hosted file}

\verb`Tables.docx`  available at \url{https://authorea.com/users/508243/articles/586222-a-phase-i-single-sequence-open-label-study-to-evaluate-the-drug-drug-interaction-between-hetrombopag-and-cyclosporine-in-healthy-chinese-subjects}

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