CONCLUSIONS
This study showed a higher MMP-2 concentration in children presenting
with tympanic atrophy, while the TIMP-2 concentration was lower in this
group, suggesting a role of MMP-2 in the digestion of type IV collagen
from the basement membrane of the tympanum. This study also suggests a
higher concentration of MMP-9 and TIMP-2 in case of thicker, mucous
effusions. The level of MMP-2 decreased with the age, suggesting more
aggressive OME in young children leading to atrophy. In the future,
MMP-2 concentration assessment could refine the indications for the
insertion of VT in children to prevent the emergence of cholesteatoma.