Serial number
Sex
Age (years)
Age (years)
Dasatinib dose (mg/d)
Clinical presentation
PASP (mmHg)
Pleural effusion
Pericardial effusion
PAH appearance time (months)
Treatment plan
Evaluation time (months)
Evaluation results
1[10] Male 41 140 140 Dyspnea, cough, edema NA + - 26 Discontinuation + glucocorticoids + diuretics, replacement of oral nilotinib treatment 2.5 Improved
2[11] Male 48 140→50 140→50 Dyspnea, jugular vein dilation, edema, hepatosplenomegaly 61 + + 21 Discontinuation + diuretic + glucocorticoids, dasatinib reduction therapy, discontinuation after exacerbation 12 Improved
3[12] Male 70 140 140 Dyspnea NA + - 32 Discontinued + Sildenafil 7 Improved
4[13] Female 53 100→70 100→70 Dyspnea, edema, hepatosplenomegaly 65-70 - - 31 Discontinuation + sildenafil + diuretic, replacement of oral nilotinib treatment 2 Improved
5[14] Male 47 140→100 140→100 Dyspnea, jugular vein dilation, edema, hepatosplenomegaly 61 + + 39 Discontinuation + sildenafil and replace oral nilotinib treatment 6 Improved
6[15] Female 61 140→70 140→70 Dyspnea NA + + 27 Discontinuation + sildenafil and replace oral nilotinib treatment 4 Improved
7[16] Male 57 70 70 Dyspnea, edema elevated - - 37 Sildenafil + diuretic, discontinuation and replacement with nilotinib treatment 3 Improved
8[17] Female 23 140 140 Dyspnea 114 + + 35 Discontinuation + prostaglandin + diuretic, replacement of oral nilotinib treatment 9 Improved
9[18] Male 33 100 100 Dyspnea 105 - - 63 Discontinuation + sildenafil and replace oral nilotinib treatment 3 Improved
10[19] Male 50 100 100 Dyspnea, cough, chest pain 60 + - 48 Discontinuation + sildenafil and replace oral nilotinib treatment 22 Improved
11[20] Male 43 140 140 Dyspnea 90 + + 69 Discontinuation + sildenafil + calcium channel blocker + diuretic, switch to oral treatment with Ponatinib 1 Improved
12[20] Male 52 140 140 Dyspnea 75 + + 38 Discontinuation + sildenafil and replace oral nilotinib treatment 3 Improved
13[21] Male 55 100 100 Chest tightness, fatigue, edema 115 + + 36 Discontinuation + diuresis with intermittent oral dasatinib treatment 36 Improved
14[9] Female 61 140 140 Dyspnea, cough NA + - 26 Discontinuation + tadalafil + ambrisentan + diuretic, replacement of oral treatment with nilotinib 4 Improved
15[22] Male 52 NA NA Dyspnea NA - - 48 Discontinuation + Ambrisentan, replacement of oral bosutinib treatment NA Na
16[8] Female 46 70 70 Dyspnea 98 + + 144 Discontinuation + Tadalafil + Ambrisentan 2 Improved
17[23] Male 67 100 100 Dyspnea, edema NA + - 42 Discontinuation + sildenafil and replace oral imatinib treatment 1 Improved
18[24] Male 24 100 100 Dyspnea, edema NA + - 48 Discontinuation + sildenafil + bosentan + diuretic, replacement of bosutinib treatment 6 Improved
19[25] Female 46 140 140 Dyspnea, chest tightness 78 + + 59 Discontinuation + tadalafil + bosentan, replacement of oral imatinib treatment 3 Improved
20[26] Male 63 140→50 140→50 Dyspnea, jugular vein dilation, hepatosplenomegaly NA - - 60 Discontinuation + tadalafil + macitentan + sellepag and replacement of oral imatinib treatment 12 Improved
21[27] Female 73 NA NA Dyspnea NA + - 9 Discontinuation, replacement of oral imatinib treatment 12 Improved
22[28] Female 59 140 140 Dyspnea, chest pain 100 - + 54 Discontinuation + tadalafil + macitentan + diuretic + bronchodilator, replacement of nilotinib treatment 11 Improved
23[29] Male 38 NA NA Dyspnea, chest pain, cough, syncope 57 + - 18 Discontinuation + Anrisentan + Diuretic 6 Improved
24[5] Male 56 100 100 Chest tightness, shortness of breath 117 + + 47 Discontinuation + liothyronine + diuretic, resumed dasatinib treatment, replaced nilotinib + bosentan + sildenafil after exacerbation 14 Improved
25[30] Male 24 140 140 Dyspnea, jugular vein dilation 67 + - 10d Discontinue the drug 1W Improved
26[31] Male 50 140 140 Dyspnea, jugular vein dilation, edema, hepatosplenomegaly 70 + - 24 Discontinuation + bosentan + glucocorticoids + diuretics, replacement of nilotinib treatment 9 Improved
27[32] Female 47 100 100 Dyspnea, chest tightness 80 + + 15 Discontinuation + sildenafil + glucocorticoids + diuretics + tigecycline 4 Improved
28 Male 13 60 60 Cough, fatigue,shortness of breath 137 + + 75 Discontinuation + diuretic + digitalis + bosentan + poliovir + sildenafil + captopril, replacement of nilotinib treatment 3 Improved
29 Female 5 40→50 40→50 With no clinical manifestation 65 - - 6 Discontinuation + captopril + ryanodine, replacement of imatinib treatment 1 Improved