Analysis was performed to compare IFN-\(\gamma\) and IL-2 secreting PBMCs against SARS-CoV-2 BNT162b2 (Pfizer-BioNTech) mRNA vaccine in type 2 diabetic participants in context of hypertension, BMI level, gender and age, which showed robust rise of IFN-\(\gamma\) and IL-2 secreting PBMCs counts with time in type 2 diabetic group irrespective of hypertension, BMI level, gender and age. The results of Spearman’s correlation test showed significant negative correlation of HbA1c to IFN-\(\gamma\) secreting PBMCs counts (Spearman’s rho=-0.47, p =0.043) at T3 in T2DM group. Non-significant correlations of HbA1c to other parameters were shown in control group.