Characteristics of short protocol in fresh ET cycles and effect
on pregnancy outcomes
The advantages of short protocol could promote the secretion of FSH by
flare-up effect, strengthen the recruitment of early follicles, improve
the response of ovaries, and avoid the over-inhibition of long acting
GnRHa. Compared with ultra-long and long protocols, CPR and LBR were
significantly decreased. Vice versa, compared with antagonist protocol,
there were no statistical differences on IR, CPR, MR, and LBR. Sheng
compared pregnancy outcomes of ultralong, long and short protocols, and
the CPR in short protocol was 22.4%(17), which was
similar with our data. Short and antagonist protocols could not induce
hypo-estrogenism and recover potential endometrial normalization of
adenomyosis(18, 19), so when they were used, fresh ET
should be prudent because of the obviously negative pregnancy outcomes.