Methods
This was a retrospective cohort study of 91 singleton pregnancies in 73
women with adenomyosis, who were managed at a single institution.
Clinical information was retrospectively obtained from the medical
records of pregnant women with adenomyosis who were managed and
delivered after 12 weeks of gestation at the University of Tokyo
Hospital between January 2011 and December 2021. Women with artificial
abortions, multiple gestations, fetal abnormalities, or uterine
malformations were excluded from this study. Pain during pregnancy was
judged based on medical records as those having persisting pain at the
adenomyosis site with administration of analgesics for pain relief
during pregnancy; C-reactive protein (CRP) was measured while the pain
persisted.