METHODS
Our primary exposure was dichotomous high allostatic load in the
first trimester , defined as four or more out of 12 biomarkers in the
“worst” quartile. The primary outcome was new diagnosis of composite
CVD, consisting of HTN and or MD (fasting glucose greater than 100 mg/dL
or medication for diabetes). Each outcome and allostatic load component
was analyzed secondarily. Multivariable logistic regression was used to
test the association between high allostatic load and CVD adjusted for
potential confounders. Mediation and moderation analyses assessed the
role of high allostatic load in racial disparities of CVD.