For all electrode position, the permutation test revealed that the observed MI were significantly larger than the permuted MI (all p’s < 0.001, except a single MI value for the slow sleep spindles in one ANT derivation for patient #2, where p = 0.019), both in the ANT and MD, separately for the slow and fast sleep spindles (MIZ ANT fast spindle: 22.56, p < 0.001, SD: 19.00; MIZ ANT slow spindle: 22.01,p < 0.001, SD: 15.93; MIZ MD fast spindle: 92.07, p < 0.001, SD: 224.09; MIZ MD slow spindle: 89.54, p < 0.001,SD: 201.83). Figure 5 shows a representative example for spindle phase and ripple coupling in the ANT.