Appendix 1: Protocol changes
The changes to the protocol were a result of converting the original
systematic review protocol to a scoping review due to the lack of
eligible studies found on the original search. The changes included:
Changing the aim of the systematic review from evaluating the
efficiency of gabapentinoid deprescribing interventions, to including
research questions related to assessing the extent and nature of
gabapentinoid deprescribing interventions.
Expanding the population to include adults prescribed gabapentinoids
for any indication.
Appendix 2 : Search strategy
Medline, EMBASE, PsycINFO, Cochrane Central Register of
Controlled TrialsĀ (CENTRAL) and International Pharmaceutical
Abstracts (via Ovid)
((randomised controlled trial or randomized controlled trial or
controlled clinical trial or comparative study or clinical trial or
pragmatic clinical trial or cross-over stud* or random* or usual care or
active control) and (pain or adults) and (pregabalin or lyrica or
gabapentin or neurontin or gabapentinoid) and (withdraw* or wean* or
detox* or ceas* or cessation or reduc* or taper* or stop* or terminat*
or remove* or substitu* or deprescribe or discontinue* or mitigat* or
inappropriate or treatment or (therapy or therapies) or
interdisciplinary program))