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\begin{document}

\title{ETV6-NTRK3 Gene fusion positive Secretory carcinoma Breast in a two year
seven month old child with metastatic axillary lymph node: A case report
and Review of literature}



\author[1]{RESHMA BALACHANDRAN}%
\author[1]{SAJID QURESHI}%
\author[1]{GARVIT CHITKARA}%
\author[2]{TANUJA SHET}%
\author[2]{OMSHREE SHETTY}%
\author[2]{Sudeep Gupta}%
\affil[1]{Tata Memorial Centre Department of Surgical Oncology}%
\affil[2]{Tata Memorial Centre}%


\vspace{-1em}



  
  \date{May 18, 2024}


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\selectlanguage{english}
\begin{abstract}
Abstract Secretory breast carcinoma (SBC) is an exceptionally rare type
of breast carcinoma accounting for less than 0.15\% of all breast
cancers6and with varied presentations. There is a lack of consensus
regarding the exact management and there is evolving role of targeted
therapy with successful treatment outcomes. We present a case of SBC in
a two year seven month old child with axillary lymph node(ALN)
metastasis, oestrogen receptor(ER) positivity and the characteristic
ETV6-NTRK3 fusion gene expression. She was managed by surgery followed
by use of tamoxifen and targeted agent Larotrectinib. Chemoradiotherapy
was avoided considering the age and doubtful benefit. We also summarise
the pattern of presentation in SBC, treatment options and follow up
which would aid in making treatment decisions in clinical practice.
Keywords: Breast, Secretory carcinoma, ETV6-NTRK3 fusion, Larotrectinib%
\end{abstract}%



\sloppy


CASE REPORT AND REVIEW OF LITERATURE

TITLE: ETV6-NTRK3 Gene fusion positive Secretory carcinoma Breast in a
two year seven month old child with metastatic axillary lymph node: A
case report and Review of literature

Reshma R Balachandran\textsuperscript{1}, Sajid S
Qureshi\textsuperscript{1*}, Garvit Chitkara\textsuperscript{2}, Tanuja
Shet\textsuperscript{3}, Omshree Shetty\textsuperscript{4}, Sudeep
Gupta\textsuperscript{5}

\textsuperscript{1}Department of Surgical Oncology, Division of
Pediatric Surgical Oncology,Tata Memorial Hospital and Homi Bhabha
National Institute(HBNI), Mumbai, Maharashtra 400012,India

\textsuperscript{2}Department of Surgical Oncology, Division of Breast
Oncology, Tata Memorial Hospital and Homi Bhabha National
Institute(HBNI), Mumbai, Maharashtra 400012,India

\textsuperscript{3}Departement of Surgical Pathology, Tata Memorial
Hospital and Homi Bhabha National Institute(HBNI), Mumbai, Maharashtra
400012,India

\textsuperscript{4}Department of Molecular pathology and Translational
medicine, Tata Memorial Hospital and Homi Bhabha National
Institute(HBNI), Mumbai, Maharashtra 400012, India

\textsuperscript{5}Department of Medical Oncology,Tata Memorial Hospital
and Homi Bhabha National Institute(HBNI), Mumbai, Maharashtra 400012,
India

\textsuperscript{*}Corresponding author:

Sajid S Qureshi

Professor and Head

Division of Pediatric Surgical Oncology

Department of Surgical Oncology

Tata Memorial Hospital and Homi Bhabha National Institute(HBNI), Mumbai

Maharashtra 400012

India

sajidshafiques@hotmail.com

Email address of other authors:

\begin{enumerate}
\tightlist
\item
  Reshma R Balachandran resh.bala12@gmail.com
\item
  Sajid S Qureshi sajidshafiques@hotmail.com
\item
  Garvit chitkara garvit22@gmail.com
\item
  Tanuja Shet tanujashet5@gmail.com
\item
  Omshree Shetty omshreens@gmail.com
\end{enumerate}

Source of funding: None

Conflict of Interest : None

Consent to participate: NA

Ethical Approval and/or Institutional Review Board (IRB) Approval~: NA

Covering letter:

To,

The Editorial Team,

We report an extremely rare case of Secretory carcinoma breast in the
Youngest patient ever reported in literature; at the age of a two-year
seven-month old girl child. We provide the details of clinical
presentation of the disease, how to diagnose the same, and also provide
a guide to management of the same. We hope this rare case would be of
much interest to your readership and you would consider this manuscripy
for publication in your reputed journal

Thanking you in advance

Sincerely,

Sajid S Qureshi

Corresponding author

\textbf{Hosted file}

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