CASE REPORT AND REVIEW OF LITERATURE

TITLE: ETV6-NTRK3 Gene fusion positive Secretory carcinoma Breast in a two year seven month old child with metastatic axillary lymph node: A case report and Review of literature

Reshma R Balachandran¹, Sajid S Qureshi^1*, Garvit Chitkara², Tanuja Shet³, Omshree Shetty⁴, Sudeep Gupta⁵

¹Department of Surgical Oncology, Division of Pediatric Surgical Oncology,Tata Memorial Hospital and Homi Bhabha National Institute(HBNI), Mumbai, Maharashtra 400012,India

²Department of Surgical Oncology, Division of Breast Oncology, Tata Memorial Hospital and Homi Bhabha National Institute(HBNI), Mumbai, Maharashtra 400012,India

³Departement of Surgical Pathology, Tata Memorial Hospital and Homi Bhabha National Institute(HBNI), Mumbai, Maharashtra 400012,India

⁴Department of Molecular pathology and Translational medicine, Tata Memorial Hospital and Homi Bhabha National Institute(HBNI), Mumbai, Maharashtra 400012, India

⁵Department of Medical Oncology,Tata Memorial Hospital and Homi Bhabha National Institute(HBNI), Mumbai, Maharashtra 400012, India

^*Corresponding author:

Sajid S Qureshi

Professor and Head

Division of Pediatric Surgical Oncology

Department of Surgical Oncology

Tata Memorial Hospital and Homi Bhabha National Institute(HBNI), Mumbai

Maharashtra 400012

India

sajidshafiques@hotmail.com

Email address of other authors:

Source of funding: None

Conflict of Interest : None

Consent to participate: NA

Ethical Approval and/or Institutional Review Board (IRB) Approval : NA

Covering letter:

To,

The Editorial Team,

We report an extremely rare case of Secretory carcinoma breast in the Youngest patient ever reported in literature; at the age of a two-year seven-month old girl child. We provide the details of clinical presentation of the disease, how to diagnose the same, and also provide a guide to management of the same. We hope this rare case would be of much interest to your readership and you would consider this manuscripy for publication in your reputed journal

Thanking you in advance

Sincerely,

Sajid S Qureshi

Corresponding author