Voriconazole switch to fluconazole |
Voriconazole switch to fluconazole |
Voriconazole switch to fluconazole |
Voriconazole switch to
fluconazole |
Voriconazole switch to fluconazole |
Voriconazole switch
to fluconazole |
Voriconazole switch to fluconazole |
Voriconazole
switch to fluconazole |
Voriconazole switch to fluconazole |
Voriconazole switch to fluconazole |
Voriconazole switch to fluconazole |
Voriconazole switch to fluconazole |
Voriconazole switch to
fluconazole |
Voriconazole switch to fluconazole |
1
|
4.2y
M
|
Chronic granulomatous disease (HSCT)
|
Voriconazole
15.4mg/kg oral BD
|
Possible fungal infection
|
ALT
GGT
|
x4.1
x18.3
|
2
3
|
Fluconazole
7.3mg/kg oral OD
|
Drug-related hepatotoxicity
|
ALT
GGT
|
normalised
normalised
|
End of therapy
(15 weeks)
|
4
|
2
|
13.4y
M
|
Acute myeloid leukemia (induction), acute appendicitis
|
Voriconazole
12.8mg/kg oral BD
|
Fungal prophylaxis
|
GGT
|
x12.9
|
3
|
Fluconazole 11.8mg/kg oral OD
|
None given
|
GGT
|
x7.2
|
End of therapy
(1-week)
|
6
|
3
|
7.5y M
|
Acute myeloid leukemia (HSCT)
|
Voriconazole
10.0mg/kg oral BD
|
Fungal prophylaxis
|
ALT
GGT
|
x5.0
x15.5
|
2
3
|
Fluconazole
9.1mg/kg OD
|
Drug related hepatotoxicity
|
ALT
GGT
|
x2.6
x1.1
|
End of therapy
(1-week)
|
7
|
Fluconazole switch to voriconazole |
Fluconazole switch to voriconazole |
Fluconazole switch to voriconazole |
Fluconazole switch to
voriconazole |
Fluconazole switch to voriconazole |
Fluconazole switch
to voriconazole |
Fluconazole switch to voriconazole |
Fluconazole
switch to voriconazole |
Fluconazole switch to voriconazole |
Fluconazole switch to voriconazole |
Fluconazole switch to voriconazole |
Fluconazole switch to voriconazole |
Fluconazole switch to
voriconazole |
Fluconazole switch to voriconazole |
4
|
16.6y
F
|
Blastic plasmacytoid dendritic cell neoplasm (HSCT)
|
Fluconazole 4.7mg/kg oral OD
|
Fungal prophylaxis
|
GGT
|
x8.3
|
3
|
Voriconazole 2.3mg/kg oral BD
|
Febrile neutropenia - antifungal prophylaxis
|
GGT
|
normalised
|
End of therapy
(8 weeks)
|
3
|
5
|
7.0y
M
|
X-linked Hyper-IgM syndrome (HSCT)
|
Fluconazole
8.4mg/kg IV OD
|
Fungal prophylaxis
|
ALT
GGT
|
x3.5
x6.8
|
2
3
|
Voriconazole 9.0mg/kg IV
BD
|
Febrile neutropenia - treatment of possible infection
|
ALT
GGT
|
x1.4
x3.6
|
End of therapy
(<1 week)
|
2
|
Voriconazole switch to itraconazole |
Voriconazole switch to
itraconazole |
Voriconazole switch to itraconazole |
Voriconazole switch
to itraconazole |
Voriconazole switch to itraconazole |
Voriconazole
switch to itraconazole |
Voriconazole switch to itraconazole |
Voriconazole switch to itraconazole |
Voriconazole switch to
itraconazole |
Voriconazole switch to itraconazole |
Voriconazole switch
to itraconazole |
Voriconazole switch to itraconazole |
Voriconazole
switch to itraconazole |
Voriconazole switch to
itraconazole |
6
|
5.7y
M
|
T-cell acute lymphoblastic leukemia, febrile neutropenia
|
Voriconazole
7.5mg/kg oral BD
|
Fungal prophylaxis
|
GGT
|
x4.8
|
2
|
Itraconazole
(2.5mg/kg oral twice a day)
|
Drug related hepatotoxicity
|
GGT
|
x3.0
|
1-2 weeks
|
5
|
Posaconazole switch to voriconazole |
Posaconazole switch to
voriconazole |
Posaconazole switch to voriconazole |
Posaconazole switch
to voriconazole |
Posaconazole switch to voriconazole |
Posaconazole
switch to voriconazole |
Posaconazole switch to voriconazole |
Posaconazole switch to voriconazole |
Posaconazole switch to
voriconazole |
Posaconazole switch to voriconazole |
Posaconazole switch
to voriconazole |
Posaconazole switch to voriconazole |
Posaconazole
switch to voriconazole |
Posaconazole switch to
voriconazole |
7
|
15.0y
M
|
Acute myeloid leukemia relapse (HSCT)
|
Posaconazole MR 4.3mg/kg OD 5 days/week & 5.8mg/kg OD 2 days/week
|
Fungal prophylaxis
|
GGT
|
x2.8
|
2
|
Fluconazole
5.8mg/kg IV daily
|
Pre-HSCT, potential drug interactions
|
GGT
|
x1.1
|
1-2 weeks
|
3
|