Diagnosing, Imaging and Successfully Treating a Debilitating
Case of Bing-Neel Syndrome: A Multidisciplinary Feat.
Waldenstroms macroglobulinaemia (WM) is a rare B-cell lymphoma
representing ~2% of all haematological malignancies.
While most neurological complications of WM are secondary to the
overproduction of immunoglobulin M (IgM), Bing-Neel syndrome (BNS) is an
extremely rare direct central nervous system (CNS) infiltration by
malignant lymphoplasmocytic lymphoma (LPL) cells. Limited information on
BNS exists in the literature with sparse case reports and case series.
Here we present a diagnostically challenging BNS case successfully
treated with systemic chemoimmunotherapy and ibrutinib, with remarkable
clinical response.