Corresponding author:
Eivind Sørensen
Department of Internal Medicine, Diakonhjemmet Hospital
P.O.
Box 23 Vinderen, 0319 Oslo, Norway
e-mail: eivindso@alumni.ntnu.no
phone: 0047 99737439
ORCID: 0000-0002-4801-6146
Conflict of interest : Authors declare no conflict of interest
regarding the submitted article
Data availability statement: The data underlying this article
will be shared on reasonable request to the corresponding author
Funding information: This work was supported by Diakonhjemmet
Hospital, Department of Medical Research Bærum Hospital Vestre Viken
Hospital Trust, the Norwegian Institute of Public Health, the Raagholt
foundation, and the Dam foundation through a Ph.D. grant.
Ethics approval statement: The study complies with the
Declaration of Helsinki and is approved by the Regional Committee for
Medical and Health Research Ethics (ref.nr: 2016/565).
Patient consent statement: All participants gave written
consent.
Clinical trial registration : The study is registered at
ClinicalTrials.gov (NCT 03741491)
Abstract:Background: Prolonged endurance exercise is associated with an
increased risk of atrial fibrillation (AF) in men. Left atrial (LA)
dilation is a marker of pathological atrial remodeling and associated
with AF in the general population. In athletes, however, atrial dilation
is part of a physiological response to exercise, and functional
parameters may help separate physiological from pathological atrial
remodeling in this group. LA mechanical dispersion (LA MD) is a novel
marker of LA mechanical dyssynchrony associated with AF in the general
population. The associations between prolonged endurance exercise, LA MD
and AF are yet to be investigated.
Purpose: To investigate LA MD in male veteran athletes who had
regularly participated in an annual 54-kilometer cross-country (XC) ski
race in Norway with and without paroxysmal AF and to investigate the
ability of LA MD to identify veteran athletes with paroxysmal
AF.Methods: Two hundred and ninety-three men
from four groups, veteran XC skiers with (n=57) and without (n=87) AF,
and men from a non-athletic population with (n=61) and without AF (n=88)
underwent an echocardiographic exam while in sinus rhythm. Using
speckle-tracking echocardiography, LA strain was measured in each of the
six atrial segments in an atrial-focused apical four-chamber view. We
defined LA MD as the standard deviation of time-to-peak strain (SD-TPS)
and report the average from three consecutive loops.Results: XC-skiers (mean age 70.9 ± 5.7 years) reported an
average of 40-50 years of regular endurance exercise and an average of
16 completed annual Birkebeiner XC ski races. LA volumes were associated
with both AF and athletic status (p<0.001). SD-TPS was
associated with AF (p<0.001), but not with athletic status
(p=0.173). We found no significant trend between years of endurance
exercise and SD-TPS in individuals without AF (p=0.846). SD-TPS did not
add incremental value in identifying athletes with AF in addition to
clinical markers, QRS width, LA volume, and LA reservoir strain
(p=0.056).
Conclusion: LA MD was associated with paroxysmal AF regardless of
athletic status. However, it was not associated with years of performing
endurance exercise, suggesting LA MD could be a promising marker of
pathological atrial remodeling in endurance athletes, less affected by
physiological exercise-induced atrial remodeling than absolute
volumetric measurements. We found no incremental value of LA MD in
identifying veteran athletes with paroxysmal AF when LA reservoir strain
was included in the model.
Keywords: Atrial fibrillation, dyssynchrony, left atrium,
exercise, echocardiography
Abbreviations: AF, atrial fibrillation; LA, left atrium;
LAVImax, maximal left atrial volume indexed; LA MD, left
atrial mechanical dispersion; SD-TPS, standard deviation of time-to-peak
strain; LASr, left atrial reservoir strain; LV, left ventricle/left
ventricular; GLS, global longitudinal strain; XC, cross-country;