Authors contributions
Dr.Hang Li, Dr.Yang Wang, Dr. Jiahui Zhao and Dr. Xia Dou have contributed substantially to study design. Dr. Hang Li has supervised all phases of the study. Dr.Yang Wang, Dr. Jiahui Zhao, Dr. Xia Dou and Dr. Zuotao Zhao acquired data. Dr. Jiahui Zhao, Dr Hongguang Chen and Zhixin Zhang performed the analysis and interpretation of the data. Dr. Jiahui Zhao, Zhixin Zhang and Dr. Hongguang Chen drafted the manuscript and Dr. Hang Li, Dr. Yang Wang revised it critically.