4.3 (a) Predicting the identity of the TLR involved in Rv2615c
interaction
The human TLR4 (PDB ID 3FXI) and TLR2 (PDB ID: 2Z7X) protein structures
were obtained from the RCSB protein data bank. Rv2615c interactions with
TLR4 and TLR2 were compared using HADDOCK 2.2 web server (van Zundertet al. , 2016). The active sites within the TLR and Rv2615c
molecules were predicted using CastP server (Tian et al. , 2018).
Site directed docking was performed and docked complex were evaluated on
the basis of Z scores.