Subgroup Factors Numbers of Study Pooled incidence 95% CI I2 (%) P for interaction
Study design 0.670
Multi-centered 5 0.99 (0.98,1.0) 31.86
Single-centered 15 0.98 (0.95,1.0) 66.08
Follow up 0.580
<12 14 0.97 (0.97,1.0) 51.19
≥12 6 0.98 (0.98,1.0) 26.56
ICE Sample size 0.280
>100 7 0.98 (0.95,0.99) 68.51
≤100 13 0.99 (0.98,1.0) 4.01
Male proportion 0.990
<70 16 0.99 (0.97,1.0) 54.17
≥70 3 0.99 (0.97,1.0) -
Age cutoff 0.890
≥75 11 0.99 (0.97,1.0) 35.33
<75 8 0.99 (0.96,1.0) 60.83
HT proportion 0.720
<90 10 0.98 (0.96,1.0) 57.21
≥90 4 0.99 (0.97,1.0) 0
PAF proportion 0.580
>50 5 0.98 (0.96,1.0) 52.71
≤50 8 0.98 (0.96,0.99) 42.03
Devices type 0.230
Dual-seal mechanism 6 0.94 (0.94,0.99) 57.64
Single-seal mechanism 11 0.98 (0.98,1.0) 26.89
Muti-seal mechanism 2 0.96 (0.96,1.0) -