Figure Legends
Figure 1 . The human HNF4A locus harbors two promoters that produce twelve isoforms by alternative splicing.A . Schematic representation of the HNF4A gene. The nomenclature historically assigned to each exon and the options for alternative splicing between P1 and P2 promoter regions are shown.B . Human isoforms produced by HNF4A . The critical structural differences in N-terminal and C-terminal regions between the different isoforms’ subgroups are discriminated by different colors. The total number of amino acids are from the human isoforms as described in the literature, and the matching number for the murine equivalents are indicated in parentheses. The nomenclature used for each isoform corresponds with the one Lambert et al. proposed [31].
Figure 2 . Identified proteins interacting with HNF4α isoforms and involved in activation or repression of transcription . The structure of protein complexes, as displayed is based on recent studies on their crystallography. Only proteins with possible interactions with HNF4α are indicated. A color code distinguishes specific characteristics associated with HNF4α isoforms. In purple, the physical interaction with all isoforms was not demonstrated. In green, the physical interaction with P1a-α1 to α3, P1b-α4 and α5, P2a and P2b isoforms was demonstrated. In yellow, the physical interaction with P1a-α1 and α3, P1b-α4 to α6, P2a and P2b isoforms was demonstrated. In blue, physical interaction with P2a-α7 to α9 was not demonstrated. In orange, physical interaction with P1a-α1 to α3, and P2a and P2b isoforms was not demonstrated. In light blue, physical interaction with P1b, P2a and P2b isoforms was not demonstrated. In pink, physical interaction with P2b α10 to α12 was not demonstrated. In light green, physical interaction with P1a-α2, P1b-α5, P2a-α8, and P2b-α12 was not demonstrated. In dark red, physical interaction with all HNF4α isoforms was demonstrated.