Figure Legends
Figure 1 . The human HNF4A locus harbors two
promoters that produce twelve isoforms by alternative splicing.A . Schematic representation of the HNF4A gene. The
nomenclature historically assigned to each exon and the options for
alternative splicing between P1 and P2 promoter regions are shown.B . Human isoforms produced by HNF4A . The critical
structural differences in N-terminal and C-terminal regions between the
different isoforms’ subgroups are discriminated by different colors. The
total number of amino acids are from the human isoforms as described in
the literature, and the matching number for the murine equivalents are
indicated in parentheses. The nomenclature used for each isoform
corresponds with the one Lambert et al. proposed [31].
Figure 2 . Identified proteins interacting with HNF4α
isoforms and involved in activation or repression of transcription . The
structure of protein complexes, as displayed is based on recent studies
on their crystallography. Only proteins with possible interactions with
HNF4α are indicated. A color code distinguishes specific characteristics
associated with HNF4α isoforms. In purple, the physical interaction with
all isoforms was not demonstrated. In green, the physical interaction
with P1a-α1 to α3, P1b-α4 and α5, P2a and P2b isoforms was demonstrated.
In yellow, the physical interaction with P1a-α1 and α3, P1b-α4 to α6,
P2a and P2b isoforms was demonstrated. In blue, physical interaction
with P2a-α7 to α9 was not demonstrated. In orange, physical interaction
with P1a-α1 to α3, and P2a and P2b isoforms was not demonstrated. In
light blue, physical interaction with P1b, P2a and P2b isoforms was not
demonstrated. In pink, physical interaction with P2b α10 to α12 was not
demonstrated. In light green, physical interaction with P1a-α2, P1b-α5,
P2a-α8, and P2b-α12 was not demonstrated. In dark red, physical
interaction with all HNF4α isoforms was demonstrated.