Hepatocyte nuclear factor 4α multiple isoforms, their functions, and their interactomes
Jehison Alirio Herrera-Pulido, Francois-Michel Boisvert, and Francois Boudreau*
Department of Immunology and Cell Biology, Université de Sherbrooke, 3201 Rue Jean-Mignault, Sherbrooke, Québec, J1E 4K8, CANADA
*Correspondence : Pr. Francois Boudreau
Department of Immunology and Cell Biology Université de Sherbrooke 3201 Rue Jean-Mignault, Sherbrooke, QC, J1E 4K8, CANADA Phone: 1-819-821-8000 ext 72122 E-mail:Francois.Boudreau@USherbrooke.ca
Abbreviations: activator protein 1 (AP-1); AT-rich interaction domain (ARID); bromodomain containing 7 (BRD7); CREB binding protein (CBP); cytochrome P450 family 7 subfamily A member 1 (CYP7A1); DNA-binding domain (DBD); double PHD fingers 2 (DPF2); E1A binding protein P400 (EP400); enhancer of polycomb homolog 1 (EPC1); GATA zinc finger domain containing (GATAD); hepatocyte nuclear factor 4-alpha (HNF4α); histone deacetylase (HDAC); histone H4/ nucleosome acetyltransferase complex (NuA4/Tip60); human androstane receptor (hCAR); ligand binding domain (LBD); maturity-onset diabetes of the young subtype 1 (MODY1); mediator complex (MED); metastasis associated (MTA); nuclear receptor coactivator (NCOA); nuclear receptor corepressor (NCOR); nucleosome remodeling and deacetylase (NuRD); receptor interacting domain 2 (RID2); peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1); polybromo 1 (PBRM1); positive cofactor 4 (PC4); small heterodimer partner (SHP); small heterodimer partner interacting leucine zipper protein (SMILE); Switch/Sucrose-Nonfermentable (SWI/SNF); SWI/SNF related, matrix associated, actin dependent regulator of chromatin (SMARC); TATA-binding protein (TBP); transcriptional adaptor 2 (ADA2); transcription factor 4 (TCF4); transcription factor II B (TFIIB); transthyretin (TTR).
Keywords: HNF4α, alternative spliced isoforms, proteomic, transcriptome, interactome
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