2.5 | Statistical analysis
R software 4.2.1 (Vienna, Austria) was used in this study. A Pvalue of less than 0.05 (two-sided) was considered indicative of statistical significance. Categorical variables are presented as the frequency (proportion). A Cox proportional hazards model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for the risk factors for the 2-year cumulative incidence rate for CIN2+/CIN3+ in both univariate and multivariate analyses. Factors associated with progression at P <0.05 in univariate analysis were included in multivariate analysis and mutually adjusted. The 95% confidence intervals (CIs) of proportions of the 2-year cumulative incidence rates (CIRs) of CIN2+ and CIN3+ were calculated based on the exact binomial distribution. Pearson’s chi-square or Fisher’s exact probability test was used to compare the 2-year CIRs of CIN2+ and CIN3+ stratified by AHPV-GT genotyping at baseline, age at diagnosis and enrolment cytology.