2.5 | Statistical analysis
R software 4.2.1 (Vienna, Austria) was used in this study. A Pvalue of less than 0.05 (two-sided) was considered indicative of
statistical significance. Categorical variables are presented as the
frequency (proportion). A Cox proportional hazards model was used to
estimate the hazard ratio (HR) and 95% confidence interval (CI) for the
risk factors for the 2-year cumulative incidence rate for CIN2+/CIN3+ in
both univariate and multivariate analyses. Factors associated with
progression at P <0.05 in univariate analysis were
included in multivariate analysis and mutually adjusted. The 95%
confidence intervals (CIs) of proportions of the 2-year cumulative
incidence rates (CIRs) of CIN2+ and CIN3+ were calculated based on the
exact binomial distribution. Pearson’s chi-square or Fisher’s exact
probability test was used to compare the 2-year CIRs of CIN2+ and CIN3+
stratified by AHPV-GT genotyping at baseline, age at diagnosis and
enrolment cytology.