Characteristics |
CIN2+ |
CIN2+ |
CIN2+ |
CIN2+ |
CIN2+ |
CIN2+ |
CIN3+ |
CIN3+ |
CIN3+ |
|
n/N (%) |
Univariate analysis |
Univariate
analysis |
|
Multivariate analysis |
Multivariate
analysis |
n/N (%) |
Univariate analysis |
Univariate analysis |
|
|
HR (95% CI) |
P |
|
HR (95% CI) |
P |
|
HR (95% CI) |
P |
Age at diagnosis |
|
|
|
|
|
|
|
|
|
21-24 years |
2/35 (5.7%) |
0.686 (0.162-2.910) |
0.609 |
|
|
|
1/35
(2.9%) |
0.893 (0.113-7.050) |
0.914 |
≥25 years |
23/314 (7.3%) |
Reference |
|
|
|
|
9/314 (2.9%) |
Reference |
|
Marital status |
|
|
|
|
|
|
|
|
|
Married |
21/274 (7.7%) |
Reference |
|
|
|
|
8/274 (2.9%) |
Reference |
|
Single |
4/75 (5.3%) |
0.449 (0.765-6.497) |
0.142 |
|
|
|
2/75
(2.7%) |
0.343 (0.618-13.720) |
0.177 |
Childbearing |
|
|
|
|
|
|
|
|
|
≥1 |
20/273 (7.3%) |
1.096 (0.411-2.920) |
0.855 |
|
|
|
8/273
(2.9%) |
1.087 (0.231-5.122) |
0.916 |
0 |
5/76 (6.6%) |
Reference |
|
|
|
|
2/76 (2.6%) |
Reference |
|
Contraception |
|
|
|
|
|
|
|
|
|
Oral contraceptive |
6/50 (12.0%) |
2.364 (0.931-6.007) |
0.0705 |
|
|
|
2/49 (4.1%) |
1.332 (0.269-6.602) |
0.726 |
Condom |
5/90 (5.6%) |
0.785 (0.478-3.965) |
0.629 |
|
|
|
2/90
(2.2%) |
0.824 (0.166-4.086) |
0.813 |
Other |
14/209 (6.7%) |
Reference |
|
|
|
|
6/210 (2.9%) |
Reference |
|
Menopausal status |
|
|
|
|
|
|
|
|
|
Premenopause |
20/296 (6.8%) |
Reference |
|
|
|
|
8/296 (2.7%) |
Reference |
|
Menopause |
5/53 (9.4%) |
1.954 (0.779-4.902) |
0.153 |
|
|
|
2/53
(3.8%) |
1.490 (0.316-7.029) |
0.614 |
Sexual debut |
|
|
|
|
|
|
|
|
|
<20 years old |
6/57 (10.5%) |
1.809 (0.722-4.535) |
0.206 |
|
|
|
3/57 (5.3%) |
2.431 (0.627-9.421) |
0.199 |
≥20 years old |
19/292 (6.5%) |
Reference |
|
|
|
|
7/292 (2.4%) |
Reference |
|
Sexual partner |
|
|
|
|
|
|
|
|
|
≥2 |
8/65 (12.3%) |
2.491 (1.073-5.784) |
0.034 |
|
1.982 (0.843-4.663) |
0.117 |
4/65 (6.2%) |
3.389 (0.954-12.040) |
0.059 |
1 |
17/284 (6.0%) |
Reference |
|
|
|
|
6/284 (2.1%) |
Reference |
|
Enrollment cytology |
|
|
|
|
|
|
|
|
|
ASC-US/LSIL |
15/136 (11.0%) |
2.339 (1.051-5.207) |
0.037 |
|
2.081
(0.932-4.650) |
0.074 |
5/136 (3.7%) |
1.552 (0.449-5.363) |
0.487 |
NILM |
10/213 (4.7%) |
Reference |
|
|
|
|
5/213 (2.3%) |
Reference |
|
AHPV genotyping |
|
|
|
|
|
|
|
|
|
AHPV-GT+ |
11/58 (19.0%) |
4.155 (1.885-9.160) |
<0.001 |
|
3.462 (1.546-7.749) |
0.003 |
5/58 (8.6%) |
5.153 (1.490-17.820) |
0.010 |
AHPV-GT– |
14/291 (4.8%) |
Reference |
|
|
|
|
5/291 (1.7%) |
Reference |
|