2.1 | Setting and study design
From January 2017 to June 2019,
women ≥21 years old with histologic LSIL (CIN1) by colposcopy-guided
biopsy preceded by AHPV-positive/normal or mildly abnormal cytology were
prospectively recruited in the Huzhou Maternity & Child Health Care
Hospital. Women were excluded from the study based on the
following
criteria: 1) preceded by cytology of high-grade squamous intraepithelial
lesion (HSIL), atypical squamous cell cannot exclude HSIL (ASC-H),
atypical glandular cells (AGC), or adenocarcinoma in situ (AIS); 2)
previous history of CIN, cervical cancer, or other malignancies; 3)
previous therapeutic procedure performed on the cervix; 4)
immunosuppression; and 5) pregnancy. After providing written informed
consent, each woman completed a questionnaire administered by a trained
gynaecologist regarding risk factors for
hrHPV infection before clinical
examination.