DECLARATIONS
Ethics approval and consent to participate: Not applicable.
Consent for publication: Not applicable.
Availability of data and materials: All data generated or
analysed during this study are included in this published article (and
its supporting information).
Competing interests: S.A. Regnier owns stock or stock options
in Novartis. S.A. Regnier and X.Y. Lee are employees
of H. Lundbeck A/S, Copenhagen, Denmark.
Funding: Funding and support were provided by H. Lundbeck A/S,
Copenhagen, Denmark.