Clinical studies
A total of 18 articles detailing 14 studies were identified from the systematic literature review for inclusion in the meta-regression. Of these, 7 studies reported data from patients with episodic migraine only , 4 from patients with chronic migraine only , and 3 from populations including both episodic and chronic migraine . An additional 4 articles reported specific subgroup data for patients with ≥2 prior treatment failures . Details of the studies, including patient numbers, administration method, and mean (SE) change from baseline in MMDs in weeks 1–12 are shown in Table 1 . As expected, only the eptinezumab studies (PROMISE-1 , PROMISE-2 , and DELIVER ) were associated with IV administration.
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