Search Strategy
We developed a search strategy using Medical Subject Headings (MeSH) related to chemotherapy-induced ototoxicity. We searched three databases (Medline, CINHAL, and PubMed) using the following search string:(Ototoxicity OR Drug-Induced Ototoxicity OR Drug-Related Otological Toxicities OR Drug-Induced Cochleotoxicity OR Drug Induced Cochlear Toxicity OR Drug Induced Vestibulotoxicity OR vertigo OR tinnitus) AND (Antineoplastic Agent OR Anticancer Agent OR Antineoplastic Drug OR Antineoplastic OR Antitumor Drug OR Cancer Chemotherapy Agent OR Antitumor Agent OR Cancer Chemotherapy Drug OR Chemotherapeutic Anticancer Agents OR Chemotherapeutic Anticancer Drug OR Combined Antineoplastic Agents OR Antineoplastic Combined Chemotherapy Regimens) . The systematic review protocol was registered with the International Prospective Register of Systematic Reviews (CRD42022376324). The search results were downloaded into Endnote software to remove duplicates. The debugged search was uploaded to Rayyan where two reviewers (JEC and NM) screened abstracts and selected relevant titles with a 0.43 inter-rater agreement. In the event of a conflict of views, a consensus was reached through discussion. Further to ensure consistency in eligibility criteria the full texts were reviewed by the seven authors. There was a vote in case of disagreement. References from selected articles were also included. We report the results following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)(Page et al. 2021)(Figure 1.).