Weijl et al.
2004
|
RCT
50
|
Any cancer
|
100mg/m2
|
Audiometry
|
1000mg Vitamin C, 400mg Vitamin E, 100mg selenium
|
12 months
|
Patients with the highest micronutrient antioxidant score had less loss
of high-tone hearing (conduction threshold at 8.0 Hz 2.8 vs. 14.4 dB;
p=0.028).
|
Not reported
|
Villani et al.
2016
|
RCT
108
|
Solid malignancies
|
Not reported
|
Audiometry and evoked brainstem responses
|
400mg Vitamin E per day
|
3 months
|
A significant hearing loss in the control group at both 2000 Hz and 8000
Hz. Conversely, audiograms did not show significant changes in the
active group at 2000, 4000, and 8000 Hz.
|
Not reported
|
Scasso et al.
2017
|
Case-control study
26
|
Any cancer
|
100 mg/m2
|
Audiometry
|
Coenzyme Q10 + Multivitamins
|
4 months
|
A higher hearing impairment in the control patients occurred in 6 out of
8 patients (75.0%). Otherwise, only 2 out of 18 patients (11.1%) who
took the supplement daily were affected (P < 0.01).
|
Not reported
|
Campbell et al.
2022
|
RCT
27
|
Head and neck
Genitourinary
Esophagus
|
50 mg/m2
|
Audiometry
|
D-methionine (100 mg/kg) fractionated into two doses
|
5 cycles of cisplatin
|
Placebo group showed a threshold shifts from baseline to post-treatment
at 10 Hz (-13.65 dB p =0.008), 11.2 Hz (-16.15dB p=0.008) and 12.5 Hz
(-11.46dB p=0.03). The intervention group showed no significant
threshold shifts.
|
No difference between groups
|