Acknowledgements
Authors’ roles: All authors contributed to the preparation and approval
of the final manuscript. SEH, SD and KMG prepared the first draft. NCH
and CC led and oversaw the MAVIDOS trial. KMG supervised the preparation
of the manuscript and is guarantor.
For the purpose of Open Access, the author has applied a Creative
Commons Attribution (CC BY) licence to any Author Accepted Manuscript
version arising from this submission.