Results
No significant difference in neurometabolite concentrations was found
between SZ and the healthy control groups. The MAP group had lower
NAA+NAAG/Cr+PCr in left DLPFC (p<0.05) and left FWM
(p<0.05), compared to healthy controls (Figure 3). There were
no significant associations between neurometabolites, neuronal integrity
markers and peripheral cytokines. In the SZ group positive associations
were found between absolute glutamatergic and inflammatory
neurometabolites in the anterior cingulate cortex (NAA and Glu
(P<0.0001), NAA+NAAG and Glu (P<0.001), mI and Glu
(p<0.0001), mI and Glx (p<0.01)) (Figure 4). The
positive associations found between mI in the left thalamus and
mI/Cr+PCr in bilateral ACC (p<0.01) in the MAP group, were
significantly greater than these associations in healthy controls
(Figure 4).
***Figure 3***