Hardy-Weinberg balance test
A total of 189 MAUD patients were recruited in this study, aged from 18
to 60 years old (mean age=34 years [SD=7]). In case-control studies,
the Hardy-Weinberg equilibrium serves as a preliminary quality check and
constitutes the cornerstone of population genetic data research30, 31. χ2 tests were performed to
compare the distribution of observed genotypes with that was predicted
under Hardy–Weinberg equilibrium. All 8 SNPs in our genotype study were
under Hardy-Weinberg equilibrium (p>0.01), indicating that
the 8 SNPs were stable in the two population groups, which allowed us to
perform further investigations on the relationship between the phenotype
variants and the particular disease (Table 1).