Figure Legends:
Figure 1. Association between DRD4 and paranoid symptoms in MAUD patients.
A: Proportion of MAUD individuals with (red) or without (blue) paranoid symptom in the DRD4 rs1800955 TT and C+ groups.
B: Methylation level at DRD4 promoter region of the DRD4 rs1800955 TT and C+ MAUD patients.
C: Methylation level at DRD4 promoter region of the MAUD individuals with or without paranoid symptom.
D: Respective methylation degree of the CpG units in the DRD4 promoter region among the MAUD individuals with (red) and without (blue) paranoid symptom.
E: the methylation degree at the DRD4 CpG2.3 unit among the MAUD individuals with and without paranoid symptom.
F: the interaction effects of DRD4 rs1800955 polymorphism and DRD4 CpG2.3 unit methylation on the paranoid symptoms in the MAUD patients.
Figure 2. Association between COMT and impulsivity symptom in MAUD.
A: Motor impulsivity scores in MAUD individuals withthe COMT rs4818 CC and G+ genotypes.
B: Methylation level of COMT promoter region in MAUD individuals with the COMT rs4818 CC and G+ genotypes.
C: Methylation degree of the COMT CpG51.52 unit in the COMT promoter region among MAUD individuals with the COMT rs4818 CC and G+ genotypes.
D: Correlation of total methylation level of the COMT promoter region and the motor impulsivity symptoms in MAUD patients.
E: Correlation of methylation degree of the COMT CpG51.52 unit in the COMT promoter region and the motor impulsivity symptoms in MAUD patients.
F: Synergistic effects of COMT rs4818 polymorphisms and COMT methylation level on the motor impulsivity symptoms in MAUD patients.
G: Synergistic effects of COMT rs4818 polymorphisms and COMT CpG51.52 methylation on the motor impulsivity symptom in MAUD patients.
Table 1. Hardy-Weinberg equilibrium test for SNP genotyping