AUTHOR CONTRIBUTIONS
All authors made substantial contributions to this study. T.F. and QM.L. prepared the clinical samples and analyzed the data. NM.L. X.T. and F.L. helped in preparing the analyzed data. X.Z and W.H. performed data interpretation, T.F. prepared the figures, H.L. conceptualized the research and wrote the manuscript, J.L. and N.W. critically revised revision of the manuscript. All authors critically reviewed the content and approved the final version for publication.