Recently, the Niu group reported a stereoselective approach for the preparation of aryl C-glycosides through a reductive cross-coupling of glycosyl chlorides and aryl bromides, induced by photoredox/nickel catalyst (Scheme 8). [18] The reaction exhibits a wide scope of glycosyl halides and aryl bromides, producing desired products in moderate yields and with high 1,2-trans-selectivities. The configuration of glycosyl chloride coupling partners appears to have little effect on the stereochemistry of the products. Notably,
Scheme 8 Nickel-catalyzed synthesis of aryl C-glycosides using glycosyl chloride as donors