C-Glycoside Synthesis Enabled by Nickle Catalysis Weidong Shang, Rong Shi, Dawen Niu* Chin. J. Chem. 2022, 40, XXX—XXX. DOI: 10.1002/cjoc.202200XXX
C-Glycosides are critical, naturally occurring products and medicinal candidates, and extensive efforts have been made to explore efficient approaches for creating C-glycosidic bonds. Transition-metal-catalysis provides a promising strategy, particularly nickel-catalyzed C-glycosylation. However, achieving stereoselective synthesis of α- and β-C-glycosides has been a long-standing challenge. To address this problem, a variety of nickel-mediated strategies have been developed. This review highlights recent developments in nickel-catalyzed diastereoselective C-glycosylation and briefly summarizes their brief mechanistic studies.