C-Glycosides are critical, naturally occurring products and medicinal
candidates, and extensive efforts have been made to explore efficient
approaches for creating C-glycosidic bonds. Transition-metal-catalysis
provides a promising strategy, particularly nickel-catalyzed
C-glycosylation. However, achieving stereoselective synthesis of α- and
β-C-glycosides has been a long-standing challenge. To address this
problem, a variety of nickel-mediated strategies have been developed.
This review highlights recent developments in nickel-catalyzed
diastereoselective C-glycosylation and briefly summarizes their brief
mechanistic studies.
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