Key messages
- Juvenile idiopathic arthritis patients, particularly articular
patients, harbor more CD4+NKG2D+ T
cells.
- Natural-killer group 2 member D receptor directly regulates
differentiation of T cells by inducing Th1 and Th17, and decreasing
Treg and Th2.
- Natural-killer group 2 member D receptor indirectly decreases IL-10
and increases CD83, ligands of MICA, and MICB by dendritic cells.