Figure 2 NKG2D ligands are increased in active patients with different
juvenile idiopathic arthritis (JIA) subgroups. (A) Bar charts of serum
soluble NKG2D ligands MICA and MICB levels determined by ELISA from
healthy controls (HC; n = 10), systemic onset JIA (soJIA; n = 10),
pauciarticular JIA (paJIA; n = 8) and polyarticular JIA (poJIA; n = 8).
(B) Monocyte-derived dendritic cells (DCs) generated from peripheral
blood mononuclear cells (PBMCs) of healthy controls and patients of JIA
were stimulated by human IL-15 (20 ng/ml) for 24 h and then analyzed for
MICA and MICB expression by flow cytometry. (C) Bar charts of the
expression of MICA and MICB on DCs from HC (n = 10), soJIA (n = 10),
paJIA (n = 8) and poJIA (n = 8). * P < 0.01 and #P < 0.05 for within group interaction.