2.4.1 5-lipoxygenase (5-LOX)
Human B lymphocytes express 5-lipoxygenase (5-LOX) and 5-LOX activating protein (FLAP), which convert arachidonic acid to leukotrienes. 5-LOX gene expression was found to be up-regulated in B-lymphocytic leukemia (B CLL) and mantle cell lymphoma (MCL) 60, and levels of 5-LOX were associated with disease progression and recurrence in patients with B CLL. Chuanyou Xia et al 61 discovered that loss of ALOX5 gene caused a big decrease in CRISPR / Cas9-mediated migration of JeKo-1 cells, and that 5 - LOX and FLAP inhibitors reduced the adhesion of JeKo-1 cells to stromal cells 62. These results suggest that inhibition of 5-LOX may be a new therapy for MCL and certain other B-cell lymphomas.