FIGURE 1 Circadian period extension in WT by chronic caffeine treatment.
(a) and (b) are representative double-plotted actograms of WT, which are plotted on a 2 X 24-h time base. The black and white bars above the recordings represent LD cycles. Black triangles indicate the day of movement from LD to DD. The durations of the caffeine treatment are presented on the right side of the actograms. (c) Changes in the period value caused by caffeine administration and withdrawal. (c) Upper and (c) lower panels correspond to (a) and (b), respectively.
FIGURE 2 Circasemidian and circadian rhythms of CryDKOby chronic caffeine treatment.
Representative double plotted actograms of CryDKO. (a), (b), and (c) are plotted on a 2 X 24-h time base. Parts of (a) are replotted on 2 X 13.75-h (7d), 2 X 23.83-h (3d), and 2 X 15.16-h (6d) time bases. Parts of (b) are replotted on 2 X 17.08-h (7d), 2 X 14.33-h (4d), and 2 X 12.00-h (5d). Parts of (c) are replotted on 2 X 15.16-h (6d), 2 X 20.75-h (6d), and 2 X 13.08-h (3d) time bases. The black and white bars above the recordings represent the LD cycles. Black triangles indicate the day of moving from LD to DD.