FIGURE 1 Circadian period extension in WT by chronic caffeine
treatment.
(a) and (b) are representative double-plotted actograms of WT, which are
plotted on a 2 X 24-h time base. The black and white bars above the
recordings represent LD cycles. Black triangles indicate the day of
movement from LD to DD. The durations of the caffeine treatment are
presented on the right side of the actograms. (c) Changes in the period
value caused by caffeine administration and withdrawal. (c) Upper and
(c) lower panels correspond to (a) and (b), respectively.
FIGURE 2 Circasemidian and circadian rhythms of CryDKOby chronic caffeine
treatment.
Representative double plotted
actograms of CryDKO. (a), (b), and (c) are plotted on a 2 X 24-h time
base. Parts of (a) are replotted
on 2 X 13.75-h (7d), 2 X 23.83-h (3d), and 2 X 15.16-h (6d) time
bases. Parts of (b) are replotted
on 2 X 17.08-h (7d), 2 X 14.33-h (4d), and 2 X 12.00-h (5d). Parts of
(c) are replotted on 2 X 15.16-h (6d), 2 X 20.75-h (6d), and 2 X 13.08-h
(3d) time bases. The black and white bars above the recordings represent
the LD cycles. Black triangles indicate the day of moving from LD to DD.