Conclusion
In summary, we report a case of SLE with lupus hepatitis and secondary biliary tract involvement. During the diagnosis and treatment of SLE, particularly in regions with a high prevalence of hepatitis B cirrhosis like China, it is important to exclude hepatitis B or alcohol-related liver injuries and also consider differential diagnosis from other autoimmune liver diseases. Liver biopsy and liver fibrosis examination are also necessary, especially for identifying unknown causes of liver dysfunction and cirrhosis. Cholestasis provides a more comprehensive diagnosis. Hormone therapy combined with immunosuppressive therapy is recommended for these patients. In this case, the combined treatment of methylprednisolone and mycophenolate has been implemented and has demonstrated favorable results.