Individual dosing advice
To maintain a FIX level >3 IU/dL 168h after rFIX-Fc
infusion, individual doses were calculated by application of Bayesian
forecasting using the published and the novel model by taking three
clinically relevant samples into account (Figure 4). The individually
predicted Dose3% was significantly higher
(p<0.01) when predicted by the published model (median 1750 IU
(range 250-3500)) than with the novel model (median 1500 IU (range
250-2000)) when all patients were considered. Surprisingly, however,
when focusing on children <12 years no significant differences
in Dose3% were found. Median dose was 750 IU (range
250-2500) and 1000 IU (range 250-1750) (p=0.63).