Atrial proarrhythmias of ivabradine by inducing intracellular calcium overload and delayed afterdepolarizations in rabbit heart
Chengyu Wang, PhD, Mingjie Lin, PhD, Qiaomei Yang, MD, Gang Li, MD, PhD, Xiaoyan Liu, MD, PhD, Qing Zhang, MD, PhD, Shandong Yu, MD, PhD, and Lin Wu, MD
Department of Cardiology, Peking University First Hospital, 8 Xishiku Street, West District, 100034, Beijing, China
Running Title: Ivabradine induces atrial arrhythmias
Corresponding author: Lin Wu, MD,Department of Cardiology, Peking University First Hospital, No. 8, Xishiku Street, West District, Beijing, 100034, China.
Tel: 86-10-83575799
E-mail: lin_wu@163.com
Number of text pages: 20
Number of tables: 3
Number of figures: 7
Number of references: 33
Number of words in the Abstract: 245
Number of words in the Introduction: 345
Number of words in the Discussion: 1408
Abbreviations: IVA, ivabradine; HCN, hyperpolarization-activated cyclic nucleotide; AF, atrial fibrillation; AP, action potential; ATX-II, anemone toxin-II; ACh, acetylcholine; LAM, left atrial myocyte; MAP, monophasic AP; ERP, atrial effective refractory period; PRR, post-repolarization refractoriness; APA, AP amplitude; Vmax, maximum upstroke velocity of the AP; DAD, delayed afterdepolarization; EAD, early afterdepolarization; FWHE, full width at half-maximum; FDHM, full duration at half-maximum; RyR, ryanodine receptor; NCX, Na+/Ca2+ exchanger; SERCA, sarcoplasmic reticulum calcium pump.
Recommended section assignment: Cardiac EP and pharmacology