Atrial proarrhythmias of
ivabradine by inducing intracellular calcium overload and delayed
afterdepolarizations in rabbit heart
Chengyu Wang, PhD, Mingjie Lin, PhD, Qiaomei Yang, MD, Gang Li, MD, PhD,
Xiaoyan Liu, MD, PhD, Qing Zhang, MD, PhD, Shandong Yu, MD, PhD, and Lin
Wu, MD
Department of Cardiology, Peking
University First Hospital, 8 Xishiku
Street, West District, 100034, Beijing, China
Running Title: Ivabradine induces atrial arrhythmias
Corresponding author: Lin Wu, MD,Department of Cardiology, Peking
University First Hospital, No. 8, Xishiku Street, West District,
Beijing, 100034, China.
Tel:
86-10-83575799
E-mail: lin_wu@163.com
Number of text pages: 20
Number of tables: 3
Number of figures: 7
Number of references: 33
Number of words in the Abstract: 245
Number of words in the Introduction: 345
Number of words in the Discussion: 1408
Abbreviations: IVA, ivabradine; HCN, hyperpolarization-activated cyclic
nucleotide; AF, atrial fibrillation; AP, action potential; ATX-II,
anemone toxin-II; ACh, acetylcholine; LAM, left atrial myocyte; MAP,
monophasic AP; ERP, atrial effective refractory period; PRR,
post-repolarization refractoriness; APA, AP amplitude;
Vmax, maximum upstroke velocity of the AP; DAD, delayed
afterdepolarization; EAD, early afterdepolarization; FWHE, full width at
half-maximum; FDHM, full duration at half-maximum; RyR, ryanodine
receptor; NCX, Na+/Ca2+ exchanger;
SERCA, sarcoplasmic reticulum calcium pump.
Recommended section assignment: Cardiac EP and pharmacology