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\title{Physical impairments, activity limitations, and participation
restrictions of childhood acute lymphoblastic leukemia survivors: A
PETALE cohort study}



\author[1]{Annie Brochu}%
\author[2]{Dahlia Kairy}%
\author[1]{Nathalie Alos}%
\author[1]{Caroline Laverdière}%
\author[1]{Daniel Sinnett}%
\author[1]{Serge Sultan}%
\author[1]{Daniel Curnier}%
\author[1]{Marie-Claude Miron}%
\author[1]{Ramy El-Jalbout}%
\author[1]{Melissa Fiscaletti}%
\author[3]{Luc J. Hébert}%
\affil[1]{Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine}%
\affil[2]{Universite de Montreal}%
\affil[3]{Universite Laval}%


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  \date{May 17, 2024}


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\begin{abstract}
Background: Long-term musculoskeletal complications represent a growing
burden for survivors of childhood acute lymphoblastic leukemia (cALL).
This study aimed to describe impairments, activity limitations, and
participation restrictions of survivors of cALL at highest risk for late
morbidity (PETALE cohort). Procedure: This retrospective study, using
cross-sectional observational data from the PETALE cohort, included a
subgroup of survivors who presented extreme phenotypes of late effects.
Participants completed bilateral hip magnetic resonance imaging (MRI),
assessment of maximal isometric muscle strength (MIMS), range of motion
(ROM), Near Tandem Balance (NTB), 6-Minute Walk Test (6MWT), Five Time
Sit-to-Stand Test (FTSST)), and quality of life (QOL). Descriptive
statistics and regression analyses were performed. Results: 97 survivors
were included in this study. The selected survivors (24.2 \selectlanguage{ngerman}± 6.7 years
old) trended toward lower scores for most outcomes compared to available
expected values referenced from a healthy population except for QOL.
Thirteen participants (14.6\%, 18 hips) had hip ON (53.8\% male). Female
survivors had hip ON with higher severity score (66.7\% female vs.
22.2\% male). Survivors with hip ON had reduced hip external rotation
ROM compared to those without (p\textless{}0.05). Relationships were
found between MIMS and ROM outcomes, and with 6MWT. Our multiple linear
regression model explained 27.6\% of the variance of the 6MWT.
Conclusions: Although they reported QOL in the range of healthy peers,
long-term cALL survivors at highest risk for late morbidity had
clinically significant impairments and activity limitations. These data
are in keeping with the frailty phenotype described in childhood cancer
survivors.%
\end{abstract}\selectlanguage{ngerman}%



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