Detection of clinical samples
A total of 93 blood samples were collected from the First Affiliated
Hospital of Xiamen University. All samples were detected by RPCR-MC in
an extraction-free manner. The results were consistent with the results
of Sanger sequencing, as shown in Table S4. Figure 8 illustrates that
CYP2C19 * 2 heterozygosity and wild-type account for a relatively high
proportion of the Chinese population, with homozygous mutation being
relatively rare. CYP2C19 * 3 wild-type accounts for a relatively high
proportion of the population tested, heterozygosity was less common, and
mutation was the least common. CYP2C19 * 17 mostly comprised wild-type,
with mutant and heterozygosity being almost absent. These results
indicate that the polymorphism ratio of each locus in the Chinese
population is roughly consistent with previous research results.