No-Ex vs. Low-Ex | No-Ex vs. Low-Ex | No-Ex vs. High-Ex | No-Ex vs. High-Ex | Low-Ex vs. High-Ex | Low-Ex vs. High-Ex | ||
OR (95% CI) | p1 | OR (95% CI) | p2 | OR (95% CI) | p3 | p for overall model | |
Atopic dermatitis (yes vs no) |
0.001 (0.001; 0.207)
|
0.011
|
24.367 (0.113; 5268.368)
|
0.244
|
25420.421 (8.282; 78020.150)
|
0.013
|
<0.001
|
Age at 1st wheeze (per month increased) |
1.115 (0.971; 1.281)
|
1.222
|
0.390 (0.174; 0.874)
|
0.022
|
0.350 (0.151; 0.811)
|
0.014
|
<0.001
|
Haemophilus genus in the BALF (yes vs no) |
121.758 (4.836; 3065.791)
|
0.004
|
0.069 (0.001; 9.416)
|
0.287
|
0.001 (0.001; 0.231)
|
0.015
|
0.020
|
RBM-BSM distance (per 50µm increased) |
6.895 (1.568; 30.321)
|
0.011
|
0.002 (0.000; 2.303)
|
0.085
|
0.001 (0.001; 0.479)
|
0.031
|
<0.001
|
Norm. BSM area (per 5% increased) |
4.606 (1.398; 15.173)
|
0.012
|
91.105 (3.767; 2203.273)
|
0.006
|
19.778 (1.485; 263.461)
|
0.024
|
<0.001
|
BALF = Bronchoalveolar lavage fluid; PMN = Polymorphonuclear cells; RBM= Reticular basement membrane; BSM = Bronchial smooth muscle. Patients were divided according to the number of exacerbations in the year following the fibreoptic bronchoscopy in No-Ex (0 exacerbation, n=20), Low-Ex (1 or 2 exacerbations, n=27) and High-Ex (≥3 exacerbations, n=33). Parameters associated with the number of exacerbations in the year following the fibreoptic bronchoscopy were determined using stepwise multinomial logistic regression model and results were expressed for reference group vs. compared group. For each parameter, the odd ratio (OR) was presented with the 95% confidence interval. A p value < 0.05 was considered significant (bold). For each model, only parameters with significant OR were presented. An OR<1 was in favour of the reference group and an OR >1 was in favour of the compared group. | BALF = Bronchoalveolar lavage fluid; PMN = Polymorphonuclear cells; RBM= Reticular basement membrane; BSM = Bronchial smooth muscle. Patients were divided according to the number of exacerbations in the year following the fibreoptic bronchoscopy in No-Ex (0 exacerbation, n=20), Low-Ex (1 or 2 exacerbations, n=27) and High-Ex (≥3 exacerbations, n=33). Parameters associated with the number of exacerbations in the year following the fibreoptic bronchoscopy were determined using stepwise multinomial logistic regression model and results were expressed for reference group vs. compared group. For each parameter, the odd ratio (OR) was presented with the 95% confidence interval. A p value < 0.05 was considered significant (bold). For each model, only parameters with significant OR were presented. An OR<1 was in favour of the reference group and an OR >1 was in favour of the compared group. | BALF = Bronchoalveolar lavage fluid; PMN = Polymorphonuclear cells; RBM= Reticular basement membrane; BSM = Bronchial smooth muscle. Patients were divided according to the number of exacerbations in the year following the fibreoptic bronchoscopy in No-Ex (0 exacerbation, n=20), Low-Ex (1 or 2 exacerbations, n=27) and High-Ex (≥3 exacerbations, n=33). Parameters associated with the number of exacerbations in the year following the fibreoptic bronchoscopy were determined using stepwise multinomial logistic regression model and results were expressed for reference group vs. compared group. For each parameter, the odd ratio (OR) was presented with the 95% confidence interval. A p value < 0.05 was considered significant (bold). For each model, only parameters with significant OR were presented. An OR<1 was in favour of the reference group and an OR >1 was in favour of the compared group. | BALF = Bronchoalveolar lavage fluid; PMN = Polymorphonuclear cells; RBM= Reticular basement membrane; BSM = Bronchial smooth muscle. Patients were divided according to the number of exacerbations in the year following the fibreoptic bronchoscopy in No-Ex (0 exacerbation, n=20), Low-Ex (1 or 2 exacerbations, n=27) and High-Ex (≥3 exacerbations, n=33). Parameters associated with the number of exacerbations in the year following the fibreoptic bronchoscopy were determined using stepwise multinomial logistic regression model and results were expressed for reference group vs. compared group. For each parameter, the odd ratio (OR) was presented with the 95% confidence interval. A p value < 0.05 was considered significant (bold). For each model, only parameters with significant OR were presented. An OR<1 was in favour of the reference group and an OR >1 was in favour of the compared group. | BALF = Bronchoalveolar lavage fluid; PMN = Polymorphonuclear cells; RBM= Reticular basement membrane; BSM = Bronchial smooth muscle. Patients were divided according to the number of exacerbations in the year following the fibreoptic bronchoscopy in No-Ex (0 exacerbation, n=20), Low-Ex (1 or 2 exacerbations, n=27) and High-Ex (≥3 exacerbations, n=33). Parameters associated with the number of exacerbations in the year following the fibreoptic bronchoscopy were determined using stepwise multinomial logistic regression model and results were expressed for reference group vs. compared group. For each parameter, the odd ratio (OR) was presented with the 95% confidence interval. A p value < 0.05 was considered significant (bold). For each model, only parameters with significant OR were presented. An OR<1 was in favour of the reference group and an OR >1 was in favour of the compared group. | BALF = Bronchoalveolar lavage fluid; PMN = Polymorphonuclear cells; RBM= Reticular basement membrane; BSM = Bronchial smooth muscle. Patients were divided according to the number of exacerbations in the year following the fibreoptic bronchoscopy in No-Ex (0 exacerbation, n=20), Low-Ex (1 or 2 exacerbations, n=27) and High-Ex (≥3 exacerbations, n=33). Parameters associated with the number of exacerbations in the year following the fibreoptic bronchoscopy were determined using stepwise multinomial logistic regression model and results were expressed for reference group vs. compared group. For each parameter, the odd ratio (OR) was presented with the 95% confidence interval. A p value < 0.05 was considered significant (bold). For each model, only parameters with significant OR were presented. An OR<1 was in favour of the reference group and an OR >1 was in favour of the compared group. | BALF = Bronchoalveolar lavage fluid; PMN = Polymorphonuclear cells; RBM= Reticular basement membrane; BSM = Bronchial smooth muscle. Patients were divided according to the number of exacerbations in the year following the fibreoptic bronchoscopy in No-Ex (0 exacerbation, n=20), Low-Ex (1 or 2 exacerbations, n=27) and High-Ex (≥3 exacerbations, n=33). Parameters associated with the number of exacerbations in the year following the fibreoptic bronchoscopy were determined using stepwise multinomial logistic regression model and results were expressed for reference group vs. compared group. For each parameter, the odd ratio (OR) was presented with the 95% confidence interval. A p value < 0.05 was considered significant (bold). For each model, only parameters with significant OR were presented. An OR<1 was in favour of the reference group and an OR >1 was in favour of the compared group. | BALF = Bronchoalveolar lavage fluid; PMN = Polymorphonuclear cells; RBM= Reticular basement membrane; BSM = Bronchial smooth muscle. Patients were divided according to the number of exacerbations in the year following the fibreoptic bronchoscopy in No-Ex (0 exacerbation, n=20), Low-Ex (1 or 2 exacerbations, n=27) and High-Ex (≥3 exacerbations, n=33). Parameters associated with the number of exacerbations in the year following the fibreoptic bronchoscopy were determined using stepwise multinomial logistic regression model and results were expressed for reference group vs. compared group. For each parameter, the odd ratio (OR) was presented with the 95% confidence interval. A p value < 0.05 was considered significant (bold). For each model, only parameters with significant OR were presented. An OR<1 was in favour of the reference group and an OR >1 was in favour of the compared group. |