REFERENCES
1. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ
et al. Asthma and wheezing in the first six years of life. New
England Journal of Medicine 1995;332 :133–138.
2. Phelan PD, Robertson CF, Olinsky A. The Melbourne Asthma Study:
1964-1999. Journal of Allergy and Clinical Immunology2002;109 :189–194.
3. Belgrave DCM, Granell R, Turner SW, Curtin JA, Buchan IE, Le Souëf PN
et al. Lung function trajectories from pre-school age to adulthood and
their associations with early life factors: a retrospective analysis of
three population-based birth cohort studies. The Lancet
Respiratory Medicine 2018;6 :526–534.
4. Agusti A, Faner R. Lung function trajectories in health and disease.The Lancet Respiratory Medicine 2019;7 :358–364.
5. Bonner K, Scotney E, Saglani S. Factors and mechanisms contributing
to the development of preschool wheezing disorders. Expert Review
of Respiratory Medicine 2021;15 :745–760.
6. Deliu M, Fontanella S, Haider S, Sperrin M, Geifman N, Murray C et
al. Longitudinal trajectories of severe wheeze exacerbations from
infancy to school age and their association with early‐life risk factors
and late asthma outcomes. Clin Exp Allergy2020;50 :315–324.
7. Bisgaard H, Hermansen MN, Bønnelykke K, Stokholm J, Baty F, Skytt NL
et al. Association of bacteria and viruses with wheezy episodes in young
children: prospective birth cohort study. BMJ2010;341 :c4978.
8. Carlsson CJ, Vissing NH, Sevelsted A, Johnston SL, Bønnelykke K,
Bisgaard H. Duration of wheezy episodes in early childhood is
independent of the microbial trigger. Journal of Allergy and
Clinical Immunology 2015;136 :1208-1214.e5.
9. Robinson PFM, Fontanella S, Ananth S, Martin Alonso A, Cook J,
Kaya-de Vries D et al. Recurrent Severe Preschool Wheeze: From
Prespecified Diagnostic Labels to Underlying Endotypes. Am J
Respir Crit Care Med 2021;204 :523–535.
10. Robinson PFM, Pattaroni C, Cook J, Gregory L, Alonso AM, Fleming LJ
et al. Lower airway microbiota associates with inflammatory phenotype in
severe preschool wheeze. Journal of Allergy and Clinical
Immunology 2019;143 :1607-1610.e3.
11. Schwerk N, Brinkmann F, Soudah B, Kabesch M, Hansen G. Wheeze in
Preschool Age Is Associated with Pulmonary Bacterial Infection and
Resolves after Antibiotic Therapy. PLoS ONE2011;6 :e27913.
12. Henderson J, Hilliard TN, Sherriff A, Stalker D, Shammari NA, Thomas
HM et al. Hospitalization for RSV bronchiolitis before 12 months of age
and subsequent asthma, atopy and wheeze: A longitudinal birth cohort
study. Pediatric Allergy and Immunology2005;16 :386–392.
13. Sigurs N, Gustafsson PM, Bjarnason R, Lundberg F, Schmidt S,
Sigurbergsson F et al. Severe Respiratory Syncytial Virus Bronchiolitis
in Infancy and Asthma and Allergy at Age 13. Am J Respir Crit Care
Med 2005;171 :137–141.
14. Fayon M, Beaufils F, Esteves P, Campagnac M, Maurat E, Michelet M et
al. Bronchial Remodeling-based Latent Class Analysis Predicts
Exacerbations in Severe Preschool Wheezers. Am J Respir Crit Care
Med 2023;207 :416–426.
15. Hurst JR, Vestbo J, Anzueto A, Locantore N, Müllerova H, Tal-Singer
R et al. Susceptibility to Exacerbation in Chronic Obstructive Pulmonary
Disease. N Engl J Med 2010;363 :1128–1138.
16. Prevel R, Enaud R, Orieux A, Camino A, Berger P, Boyer A et al. Gut
bacteriobiota and mycobiota are both associated with Day-28 mortality
among critically ill patients. Crit Care 2022;26 :105.
17. Murray CS. Study of modifiable risk factors for asthma
exacerbations: virus infection and allergen exposure increase the risk
of asthma hospital admissions in children. Thorax2006;61 :376–382.
18. Fitzpatrick AM, Bacharier LB, Guilbert TW, Jackson DJ, Szefler SJ,
Beigelman A et al. Phenotypes of Recurrent Wheezing in Preschool
Children: Identification by Latent Class Analysis and Utility in
Prediction of Future Exacerbation. The Journal of Allergy and
Clinical Immunology: In Practice 2019;7 :915-924.e7.
19. Fitzpatrick AM, Grunwell JR, Cottrill KA, Mutic AD, Mauger DT. Blood
eosinophils for prediction of exacerbation in preschool children with
recurrent wheezing. The Journal of Allergy and Clinical
Immunology: In Practice 2023;0 . doi:10.1016/j.jaip.2023.01.037
20. Latzin P, Kuehni CE, Baldwin DN, Roiha HL, Casaulta C, Frey U.
Elevated Exhaled Nitric Oxide in Newborns of Atopic Mothers Precedes
Respiratory Symptoms. Am J Respir Crit Care Med2006;174 :1292–1298.
21. Simpson A, Tan VYF, Winn J, Svensén M, Bishop CM, Heckerman DE et
al. Beyond Atopy: Multiple Patterns of Sensitization in Relation to
Asthma in a Birth Cohort Study. American Journal of Respiratory
and Critical Care Medicine 2010;181 :1200–1206.
22. Bacharier LB, Guilbert TW, Jartti T, Saglani S. Which Wheezing
Preschoolers Should be Treated for Asthma? The Journal of Allergy
and Clinical Immunology: In Practice 2021;9 :2611–2618.
23. de Boer GM, Żółkiewicz J, Strzelec KP, Ruszczyński M, Hendriks RW,
Braunstahl G-J et al. Bacterial lysate therapy for the prevention of
wheezing episodes and asthma exacerbations: a systematic review and
meta-analysis. Eur Respir Rev 2020;29 :190175.
24. Nieto A, Mazón A, Nieto M, Calderón R, Calaforra S, Selva B et al.
Bacterial Mucosal Immunotherapy with MV130 Prevents Recurrent Wheezing
in Children: A Randomized, Double-Blind, Placebo-controlled Clinical
Trial. Am J Respir Crit Care Med 2021;204 :462–472.
25. Girodet P-O, Allard B, Thumerel M, Begueret H, Dupin I, Ousova O et
al. Bronchial smooth muscle remodeling in nonsevere asthma.American Journal of Respiratory and Critical Care Medicine2016;193 :627–633.
26. Bonato M, Bazzan E, Snijders D, Tinè M, Biondini D, Turato G et al.
Clinical and pathologic factors predicting future asthma in wheezing
children. A longitudinal study. American Journal of Respiratory
Cell and Molecular Biology 2018;59 :458–466.
27. Pretolani M, Bergqvist A, Thabut G, Dombret M-C, Knapp D, Hamidi F
et al. Effectiveness of bronchial thermoplasty in patients with severe
refractory asthma: Clinical and histopathologic correlations.Journal of Allergy and Clinical Immunology2017;139 :1176–1185.
28. Fayon M, Beaufils F. The lower respiratory airway wall in children
in health and disease. ERJ Open Res 2021;7 :00874–02020.
29. Wang KCW, Donovan GM, Saglani S, Mauad T, James AL, Elliot JG et al.
Growth of the airway smooth muscle layer from late gestation to
childhood is mediated initially by hypertrophy and subsequently
hyperplasia. Respirology 2022;27 :493–500.
30. Fayon M, Andrieux A, Bara I, Rebola M, Labbé A, Marthan R et al. An
Age-Wise Comparison of Human Airway Smooth Muscle Proliferative
Capacity. PLOS ONE 2015;10 :e0122446.
31. Beaufils F, Esteves P, Enaud R, Germande O, Celle A, Marthan R et
al. Mitochondria are involved in bronchial smooth muscle remodeling in
severe preschool wheezers. J Allergy Clin Immunol2021;148 :645-651.e11.
32. Trian T, Benard G, Begueret H, Rossignol R, Girodet P-O, Ghosh D et
al. Bronchial smooth muscle remodeling involves calcium-dependent
enhanced mitochondrial biogenesis in asthma. J Exp Med2007;204 :3173–3181.
33. Esteves P, Allard B, Celle A, Dupin I, Maurat E, Ousova O et al.
Asthmatic bronchial smooth muscle increases rhinovirus replication
within the bronchial epithelium. Cell Reports2022;38 :110571.
34. Celle A, Esteves P, Cardouat G, Beaufils F, Eyraud E, Dupin I et al.
Rhinovirus infection of bronchial epithelium induces specific bronchial
smooth muscle cell migration of severe asthmatic patients. J
Allergy Clin Immunol 2022;:S0091-6749(22)00148-8.
35. Saglani S, Baraldo S. Remodelling Phenotypes Take Centre Stage in
the Prediction of Preschool Wheeze Attacks. Am J Respir Crit Care
Med Published Online First: 28 September 2022.
doi:10.1164/rccm.202209-1833ED