Malaria is a major public health issue in many parts of the world, particularly in sub-Saharan Africa, where it accounts for a significant burden of morbidity and mortality. In Sudan, the disease is endemic and poses a serious health risk to the population. We present a case of severe malaria caused by Plasmodium falciparum in an 18-year-old male who presented with fever and headache. Despite initial treatment with antibiotics and antimalarials, the patient’s condition deteriorated, and he developed severe anemia and subconjunctival hemorrhage. This case highlights the importance of early and accurate diagnosis, prompt treatment, and ongoing monitoring of patients with malaria to prevent the development of severe complications. It also underscores the need for increased efforts to control and eradicate malaria in endemic regions, including improved access to effective antimalarial drugs and the development of effective prevention strategies. Understanding the clinical presentation and management of severe malaria is critical for reducing the burden of this deadly disease in affected populations.