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1. Sakaguchi S, et al. Regulatory T Cells and Immune Tolerance.Cell 2008;133(5):775–787.
2. Plitas G, Rudensky AY. Regulatory T cells: Differentiation and
function. Cancer Immunol. Res. 2016;4(9):721–725.
3. Atif M, et al. Regulatory T cells in solid organ transplantation.Clin. Transl. Immunol. 2020;9(2):1–15.
4. Guo WW, et al. Regulatory T Cells in GVHD Therapy. Front.
Immunol. 2021;12(June). doi:10.3389/fimmu.2021.697854
5. Esensten JH, et al. Regulatory T-cell therapy for autoimmune and
autoinflammatory diseases: The next frontier. J. Allergy Clin.
Immunol. 2018;142(6):1710–1718.
6. Raffin C, Vo LT, Bluestone JA. T reg cell-based therapies :
challenges and perspectives2021;20(3):158–172.
7. Mohseni YR, et al. The Future of Regulatory T Cell Therapy: Promises
and Challenges of Implementing CAR Technology. Front. Immunol.2020;11(July):1–13.
8. Bluestone JA, et al. Type 1 diabetes immunotherapy using polyclonal
regulatory T cells2015;7(315).
9. Seddiki N, et al. Expression of interleukin (IL)-2 and IL-7 receptors
discriminates between human regulatory and activated T cells. J.
Exp. Med. 2006;203(7):1693–1700.
10. Hoffmann P, et al. Large-scale in vitro expansion of polyclonal
human CD4+CD25 high regulatory T cells. Blood2004;104(3):895–903.
11. Vignali D, et al. Detection and characterization of CD8 +
autoreactive memory stem T cells in patients with type 1 diabetes.Diabetes 2018;67(May):936–945.
12. Heninger A-K, et al. IL-7 abrogates suppressive activity of human
CD4+ CD25 + FOXP3+ regulatory T cells and allows expansion of
alloreactive and autoreactive T cells. J. Immunol. 2012;189(12).
doi:10.4049/jimmunol.1201286
13. Vignali D, et al. IL-7 Mediated Homeostatic Expansion of Human
CD4+CD25+FOXP3+ Regulatory T Cells After Depletion With Anti-CD25
Monoclonal Antibody2016;100(9). doi:10.1097/TP.0000000000001276
14. Liu W, et al. CD127 expression inversely correlates with FoxP3 and
suppressive function of human CD4+ T reg cells. J. Exp. Med.2006;203(7):1701–1711.
15. Ryan BDH, et al. and B-Lineage Differentiation Capacity1997;
16. Monti P, et al. Disengaging the IL-2 receptor with daclizumab
enhances IL-7-mediated proliferation of CD4+ and
CD8+ T Cells. Am. J. Transplant. 2009;9(12).
doi:10.1111/j.1600-6143.2009.02825.x
17. Battaglia M, Stabilini A, Roncarolo MG. Rapamycin selectively
expands CD4+CD25+FoxP3 + regulatory T cells. Blood2005;105(12):4743–4748.
18. Putnam AL, et al. Expansion of human regulatory T-cells from
patients with type 1 diabetes. Diabetes 2009;58(3):652–662.
19. MacDonald KN, Piret JM, Levings MK. Methods to manufacture
regulatory T cells for cell therapy. Clin. Exp. Immunol.2019;197(1):52–63.
20. Tan JT, et al. IL-7 is critical for homeostatic proliferation and
survival of naïve T cells. Proc. Natl. Acad. Sci. U. S. A.2001;98(15):8732–8737.
21. Chetoui N, et al. Interleukin-7 promotes the survival of human CD4+
effector/memory T cells by up-regulating Bcl-2 proteins and activating
the JAK/STAT signalling pathway. Immunology 2010;130(3):418–426.
22. Manuscript A. NIH Public Access2013;24(3):209–217.
23. Gattinoni L, et al. A human memory T cell subset with stem cell-like
properties. Nat. Med. 2011;17(10):1290–1297.
24. Motwani K, et al. Human Regulatory T Cells From Umbilical Cord Blood
Display Increased Repertoire Diversity and Lineage Stability Relative to
Adult Peripheral Blood. Front. Immunol. 2020;11(April):1–17.
25. Procaccini C, et al. An Oscillatory Switch in mTOR Kinase Activity
Sets Regulatory T Cell Responsiveness. Immunity2010;33(6):929–941.
26. Angelin A, et al. Foxp3 Reprograms T Cell Metabolism to Function in
Low-Glucose, High-Lactate Environments. Cell Metab.2017;25(6):1282-1293.e7.
27. Issa F. Foxp3 and Toll-Like Receptor Signaling Balance Treg Cell
Anabolic Metabolism for Suppression. Transplantation2017;101(2):218.
28. Shi LZ, et al. HIF1α-dependent glycolytic pathway orchestrates a
metabolic checkpoint for the differentiation of TH17 and Treg cells.J. Exp. Med. 2011;208(7):1367–1376.
29. Pacella I, et al. Fatty acid metabolism complements glycolysis in th
selective regulatory t cell expansion during tumor growth. Proc.
Natl. Acad. Sci. U. S. A. 2018;115(28):E6546–E6555.
30. Kishore M, et al. Regulatory T Cell Migration Is Dependent on
Glucokinase-Mediated Glycolysis. Immunity 2017;47(5):875-889.e10.
31. Fritzsching B, et al. Naive regulatory T cells: A novel
subpopulation defined by resistance toward CD95L-mediated cell death.Blood 2006;108(10):3371–3378.
32. Patrick MS, et al. Human T cell differentiation negatively regulates
telomerase expression resulting in reduced activation-induced
proliferation and survival. Front. Immunol. 2019;10(AUG):1–11.