Company Sankyo Merck Merck Sankyo Sandoz Pfizer AstraZeneca JINGXIN
Half-life / 3 h 2-3 h 1.5 h 2.3±0.9 h 14 h 19 h 11 h
Clearance / Hepatic Hepatic Hepatic and renal Hepatic Hepatic Hepatic and renal Hepatic
Form Administered / Inactive lactone Inactive lactone Active hydroxy acid Active hydroxy acid Active hydroxy acid Active hydroxy acid Active hydroxy acid
Solubility / Lipophilic Lipophilic Hydrophilic Lipophilic Lipophilic Hydrophilic Lipophilic
Derivative Fungal Fungal Fungal Fungal Synthetic Synthetic Synthetic Synthetic
Structure
Generation / First First Second Second Third Third Third
Drug name Compactin Lovastatin Simvastatin Pravastatin Fluvastatin Atorvastatin Rosuvastatin Pitavastatin