Anaphylaxis Predictors
A significant association was found between anaphylaxis and allergy to chestnut (OR 5.023 [IC 95% 1.691-14.922], p=0.002) and cashew (OR 2.901 [IC 95% 1.184-7.107], p=0.018) (Figure 2A ). Reaction severity was independent of the number of nut sensitizations (p=0.655). Considering SPPT, MPD was significantly higher in G1 for almond (6.5 vs 4mm, p=0.015), cashew (10 vs 5mm, p=0.049) and pistachio (8 vs 3.75mm, p=0.046) (Figure 2B ). sIgE values were not good predictors of reaction severity for any nut (Figure 2C ). However, a significantly higher value of sIgE/total IgE ratio was found in G1 for walnut (0.0125 vs 0.0005, p=0.023) (Figure 2D ). There was no significant association between symptoms severity and serum eosinophils (682.9 vs 596.6/µL, p=0.261) or total IgE (603.4 vs 1879.6 kUA/L, p=0.068). As for the mcIgE, peanut Ara h2 and Ara h6 were identified in more patients from G1 vs G2, with higher median mcIgE values (2.8 vs 0 ISU-E, p 0.042; 1.3 vs 0 ISU-E, p=0.020) (Figure 2E ).