6.2 Cardiovascular disease
The pathogenesis of cardiovascular disease (CVD) is complex and diverse,
and it is also one of the diseases with the highest mortality in the
world, including atherosclerosis, arrhythmia, hypertension, and
aneurysm[66,67,68]. With the development of
medical technology, scholars have gradually realized that the
pathogenesis of cardiovascular disease is complex and involves multiple
targets[69]. At this time, network pharmacology
has been a concern for more and more scholars, and occupies an important
position in the mechanism research and drug development of
cardiovascular disease treatment. Yu[70] et al.
Explored the effects of wild ginseng and garden ginseng on
cardiovascular diseases by combining metabonomics and network
pharmacology, and found that both kinds of ginseng can pass HIF-1 α/ The
vascular endothelial growth factor signaling pathway protects the
injured internode vessels, and determines the potential mechanism of
different metabolites in CVD. Zhang [71] et al.
Discovered Rehmannia glutinosa (RRP) as a new potential herbal medicine
against cardiovascular disease through network pharmacology, and put
forward new opinions on the molecular mechanism of RRP-mediated
anti-atherosclerosis (AS).