5 Sepsis - multiple organs
The key inducing factor of sepsis-related multiple organ injury is the
uncontrolled persistent inflammatory response, especially for patients
with organ dysfunction in the past, which will aggravate the further
deterioration of sepsis-related organ dysfunction[45]. When organ dysfunction occurs in
hospitalized patients with sepsis, even mild organ injury can cause
about 10% of the in-hospital mortality. At present, the SOFA score of
sepsis-related organ failure has also been developed. Taking the SOFA
score of 2 as the dividing point, the death risk of patients with SOFA
scores greater than 2 is 2 to 25 times higher than that of patients with
SOFA scores less than 2 [46,47]. At present, the
discovery of new bioactive ingredients and the reuse of traditional
drugs through network pharmacological methods have shown some
effectiveness in the treatment of sepsis with organ dysfunction.