6.1 Cancer
Cancer is a disease caused by the abnormality of a complex biological
network. Some drugs targeting a single target or pathway in the past may
not achieve the expected effect in the treatment of some malignant
tumors [61]. Therefore, using a system network
method to find therapeutic drugs has become a reliable method. This
strategy helps to identify the specific signal pathways driving
tumor-promoting or anti-tumor signals, and improve drug reuse and
development[62,63]. Wu[64]et al. Used weighted gene coexpression network analysis (WGCNA) and
network pharmacology to explore the potential mechanism of Compound
Kushen Injection (CKI) in the treatment of pancreatic cancer (PC). After
molecular docking and experimental verification, they finally found that
CDK1, Jak1, EGFR, mapk1, and mapk3 were the core genes regulated by CKI
in the treatment of PC. Wo [65] et al. Screened 28
important proteins of four kinds of cancer (bladder cancer, colorectal
cancer, liver cancer, and lung cancer) through system biology and
computer assistance, and found new drug pathways with multiple target
effects through systematic evaluation and analysis.