6.3 Mental illness
Severe mental illness is a multifactorial disease, with about 4.5% of the population suffering from severe mental illness (SMI)[72]. Depression is a common disease in mental diseases. Zhang [73] and others found that Radix Bupleuri and Radix Paeoniae Alba play an antidepressant role by using metabonomics and network pharmacology research strategies, and found that CYP1A1 and CYP1A2 proteins are the key genes of the drug for antidepressants. Qi [74] et al. Established a network assessment and analysis to determine the signal pathways mainly involved in the targets related to severe mental diseases. Then the experiment confirmed that Coptis extract can improve anxiety-like behavior by improving the survival rate of neurons and inhibiting neuroinflammation.