5.2 Kidney
Sepsis kidney injury is closely related to the clinical prognosis of
patients. About one-third of patients with sepsis will develop into
sepsis kidney injury. The mortality of patients with sepsis kidney
injury is higher than that of patients without sepsis kidney injury[52,53]. Yao [54] et al.
Discussed the protective effect of saikosaponin d (SA) on sepsis-induced
renal injury by using network pharmacology analysis and bioinformatics
analysis. The double luciferase reporter gene and chromatin
immunoprecipitation (chip) experiments found that SA reduced the
expression of apoptosis and inflammatory factors by inhibiting the
tcf7/fosl1/mmp9 axis, and ultimately reduced the renal inflammation and
apoptosis induced by sepsis, to protect a sepsis-induced renal injury.
Tang [55] et al. Found that Astragalus
membranaceus and astragaloside IV (as-iv) protect renal tubular injury
induced by sepsis by activating Pi3k/akt pathway based on network
pharmacology.