6.3 Mental illness
Severe mental illness is a multifactorial disease, with about 4.5% of
the population suffering from severe mental illness (SMI)[72]. Depression is a common disease in mental
diseases. Zhang [73] and others found that Radix
Bupleuri and Radix Paeoniae Alba play an antidepressant role by using
metabonomics and network pharmacology research strategies, and found
that CYP1A1 and CYP1A2 proteins are the key genes of the drug for
antidepressants. Qi [74] et al. Established a
network assessment and analysis to determine the signal pathways mainly
involved in the targets related to severe mental diseases. Then the
experiment confirmed that Coptis extract can improve anxiety-like
behavior by improving the survival rate of neurons and inhibiting
neuroinflammation.