5.2 Kidney
Sepsis kidney injury is closely related to the clinical prognosis of patients. About one-third of patients with sepsis will develop into sepsis kidney injury. The mortality of patients with sepsis kidney injury is higher than that of patients without sepsis kidney injury[52,53]. Yao [54] et al. Discussed the protective effect of saikosaponin d (SA) on sepsis-induced renal injury by using network pharmacology analysis and bioinformatics analysis. The double luciferase reporter gene and chromatin immunoprecipitation (chip) experiments found that SA reduced the expression of apoptosis and inflammatory factors by inhibiting the tcf7/fosl1/mmp9 axis, and ultimately reduced the renal inflammation and apoptosis induced by sepsis, to protect a sepsis-induced renal injury. Tang [55] et al. Found that Astragalus membranaceus and astragaloside IV (as-iv) protect renal tubular injury induced by sepsis by activating Pi3k/akt pathway based on network pharmacology.