5 Sepsis - multiple organs
The key inducing factor of sepsis-related multiple organ injury is the uncontrolled persistent inflammatory response, especially for patients with organ dysfunction in the past, which will aggravate the further deterioration of sepsis-related organ dysfunction[45]. When organ dysfunction occurs in hospitalized patients with sepsis, even mild organ injury can cause about 10% of the in-hospital mortality. At present, the SOFA score of sepsis-related organ failure has also been developed. Taking the SOFA score of 2 as the dividing point, the death risk of patients with SOFA scores greater than 2 is 2 to 25 times higher than that of patients with SOFA scores less than 2 [46,47]. At present, the discovery of new bioactive ingredients and the reuse of traditional drugs through network pharmacological methods have shown some effectiveness in the treatment of sepsis with organ dysfunction.