5.1 Lungs
In the intensive care unit (ICU), sepsis is the main indirect cause of ali/ards. In addition, the lung is the first affected and most vulnerable organ in sepsis [48,49]. In severe sepsis, as time goes on, acute lung injury can develop into pulmonary fibrosis, resulting in respiratory failure and death[50]. Yang [51] et al. Predicted the active ingredients and effective targets of Lianhua Qingwen (lhqw) in the treatment of acute lung injury (ALI) caused by sepsis by using the network pharmacological method. Through GO and KEGG, they found that the apoptosis pathway was mainly involved in lhqw’s anti-Ali. Further animal experiments confirmed that lhqw could increase the expression of Bcl-2, reduce the release of cytochrome c, and inhibit the over-expression of p53 induced by LPS by reducing the levels of Caspase-3 and caspase-9 in Ali mice, Inhibiting p53 mediated endogenous apoptosis pathway and alleviating sepsis-induced lung injury.