References
- Funk DJ, Parrillo JE, Kumar A.
Sepsis and septic shock: a history. Crit Care Clin. 2009
Jan;25(1):83-101, viii.
- Cecconi M, Evans L, Levy M, Rhodes A. Sepsis and septic shock. Lancet.
2018 Jul 7;392(10141):75-87.
- Evans L, Rhodes A, Alhazzani W, et al. Surviving Sepsis Campaign:
International Guidelines for Management of Sepsis and Septic Shock
2021. Crit Care Med. 2021 Nov 1;49(11):e1063-e1143.
- Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T,
Schlattmann P, Angus DC, Reinhart K; International Forum of Acute Care
Trialists. Assessment of Global Incidence and Mortality of
Hospital-treated Sepsis. Current Estimates and Limitations. Am J
Respir Crit Care Med. 2016 Feb 1;193(3):259-72.
- Zhang Y, Cao B, Cao W, Miao H, Wu L. Clinical Characteristics and
Death Risk Factors of Severe Sepsis in Children. Comput Math Methods
Med. 2022 Jan 24;2022:4200605.
- Font MD, Thyagarajan B, Khanna AK. Sepsis and Septic Shock - Basics of
diagnosis, pathophysiology and clinical decision making. Med Clin
North Am. 2020 Jul;104(4):573-585.
- Lelubre C, Vincent JL. Mechanisms and treatment of organ failure in
sepsis. Nat Rev Nephrol. 2018 Jul;14(7):417-427.
- Esposito S, De Simone G, Boccia G, De Caro F, Pagliano P. Sepsis and
septic shock: New definitions, new diagnostic and therapeutic
approaches. J Glob Antimicrob Resist. 2017 Sep;10:204-212.
- Muhammad J, Khan A, Ali A, Fang L, Yanjing W, Xu Q, Wei DQ. Network
Pharmacology: Exploring the Resources and Methodologies. Curr Top Med
Chem. 2018;18(12):949-964.
- Boezio B, Audouze K, Ducrot P, Taboureau O. Network-based Approaches
in Pharmacology. Mol Inform. 2017 Oct;36(10).
- Nogales C, Mamdouh ZM, List M, Kiel C, Casas AI, Schmidt HHHW. Network
pharmacology: curing causal mechanisms instead of treating symptoms.
Trends Pharmacol Sci. 2022 Feb;43(2):136-150.
- Yildirim MA, Goh KI, Cusick ME, Barabási AL, Vidal M. Drug-target
network. Nat Biotechnol. 2007 Oct;25(10):1119-26.
- Hopkins AL. Network pharmacology. Nat Biotechnol. 2007
Oct;25(10):1110-1.
- Jacunski A, Tatonetti NP. Connecting the dots: applications of network
medicine in pharmacology and disease. Clin Pharmacol Ther. 2013
Dec;94(6):659-69.
- Zhang R, Zhu X, Bai H, Ning K. Network Pharmacology Databases for
Traditional Chinese Medicine: Review and Assessment. Front Pharmacol.
2019 Feb 21;10:123.
- Luo TT, Lu Y, Yan SK, Xiao X, Rong XL, Guo J. Network Pharmacology in
Research of Chinese Medicine Formula: Methodology, Application and
Prospective. Chin J Integr Med. 2020 Jan;26(1):72-80.
- Wang X, Wang ZY, Zheng JH, Li S. TCM network pharmacology: A new trend
towards combining computational, experimental and clinical approaches.
Chin J Nat Med. 2021 Jan;19(1):1-11.
- Dai YJ, Wan SY, Gong SS, Liu JC, Li F, Kou JP. Recent advances of
traditional Chinese medicine on the prevention and treatment of
COVID-19. Chin J Nat Med. 2020 Dec;18(12):881-889.
- Zhou Y, Hou Y, Shen J, Huang Y, Martin W, Cheng F. Network-based drug
repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2. Cell Discov.
2020 Mar 16;6:14.
- Su H, Wu G, Zhan L, Xu F, Qian H, Li Y, Zhu X. Exploration of the
Mechanism of Lianhua Qingwen in Treating Influenza Virus Pneumonia and
New Coronavirus Pneumonia with the Concept of ”Different Diseases with
the Same Treatment” Based on Network Pharmacology. Evid Based
Complement Alternat Med. 2022 Feb 8;2022:5536266.
- Lei S, Lei X, Liu L. Drug repositioning based on heterogeneous
networks and variational graph autoencoders. Front Pharmacol. 2022 Dec
21;13:1056605.
- Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N,
Schwikowski B, Ideker T. Cytoscape: a software environment for
integrated models of biomolecular interaction networks. Genome Res.
2003 Nov;13(11):2498-504.
- Trott O, Olson AJ. AutoDock Vina: improving the speed and accuracy of
docking with a new scoring function, efficient optimization, and
multithreading. J Comput Chem. 2010 Jan 30;31(2):455-61.
- Hugo Montes A, Valle-Garay E, Martin G, Collazos J, Alvarez V, Meana
A, Pérez-Is L, Carton JA, Taboada F, Asensi V. The TNF-α (-238 G/A)
polymorphism could protect against development of severe sepsis.
Innate Immun. 2021 Jul;27(5):409-420.
- Fisher CJ Jr, Dhainaut JF, Opal SM, et al. Recombinant human
interleukin 1 receptor antagonist in the treatment of patients with
sepsis syndrome. Results from a randomized, double-blind,
placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study
Group. JAMA. 1994 Jun 15;271(23):1836-43.
- Huang Y, Zang K, Shang F, Guo S, Gao L, Zhang X. HMGB1 mediates acute
liver injury in sepsis through pyroptosis of liver macrophages. Int J
Burns Trauma. 2020 Jun 15;10(3):60-67.
- Andersson U, Yang H. HMGB1 is a critical molecule in the pathogenesis
of Gram-negative sepsis. J Intensive Med. 2022 Mar 9;2(3):156-166.
- Chen L, Lu Q, Deng F, Peng S, Yuan J, Liu C, Du X. miR-103a-3p Could
Attenuate Sepsis-Induced Liver Injury by Targeting HMGB1.
Inflammation. 2020 Dec;43(6):2075-2086.
- Liu YC, Zou XB, Chai YF, Yao YM. Macrophage polarization in
inflammatory diseases. Int J Biol Sci. 2014 May 1;10(5):520-9.
- Kumar V. Targeting macrophage immunometabolism: Dawn in the darkness
of sepsis. Int Immunopharmacol. 2018 May;58:173-185. doi:
10.1016/j.intimp.2018.03.005. Epub 2018 Apr 3.
- Liao ST, Han C, Xu DQ, Fu XW, Wang JS, Kong LY. 4-Octyl itaconate
inhibits aerobic glycolysis by targeting GAPDH to exert
anti-inflammatory effects. Nat Commun. 2019 Nov 8;10(1):5091.
- Hu Q, Lyon CJ, Fletcher JK, Tang W, Wan M, Hu TY. Extracellular
vesicle activities regulating macrophage- and tissue-mediated injury
and repair responses. Acta Pharm Sin B. 2021 Jun;11(6):1493-1512.
- Gao YL, Zhai JH, Chai YF. Recent Advances in the Molecular Mechanisms
Underlying Pyroptosis in Sepsis. Mediators Inflamm. 2018 Mar
7;2018:5823823.
- Pai MH, Wu JM, Yang PJ, Lee PC, Huang CC, Yeh SL, Lin MT. Antecedent
Dietary Glutamine Supplementation Benefits Modulation of Liver
Pyroptosis in Mice with Polymicrobial Sepsis. Nutrients. 2020 Apr
14;12(4):1086.
- Ward PA, Gao H. Sepsis, complement and the dysregulated inflammatory
response. J Cell Mol Med. 2009 Oct;13(10):4154-60.
- Wood AJT, Vassallo A, Summers C, Chilvers ER, Conway-Morris A. C5a
anaphylatoxin and its role in critical illness-induced organ
dysfunction. Eur J Clin Invest. 2018 Dec;48(12):e13028.
- Sommerfeld O, Medyukhina A, Neugebauer S, Ghait M, Ulferts S, Lupp A,
König R, Wetzker R, Schulz S, Figge MT, Bauer M, Press AT. Targeting
Complement C5a Receptor 1 for the Treatment of Immunosuppression in
Sepsis. Mol Ther. 2021 Jan 6;29(1):338-346.
- Zhang YY, Ning BT. Signaling pathways and intervention therapies in
sepsis. Signal Transduct Target Ther. 2021 Nov 25;6(1):407.
- Yuan H, Ma Q, Cui H, Liu G, Zhao X, Li W, Piao G. How Can Synergism of
Traditional Medicines Benefit from Network Pharmacology? Molecules.
2017 Jul 7;22(7):1135.
- Salomão R, Ferreira BL, Salomão MC, Santos SS, Azevedo LCP, Brunialti
MKC. Sepsis: evolving concepts and challenges. Braz J Med Biol Res.
2019;52(4):e8595.
- Zhou W, Lai X, Wang X, Yao X, Wang W, Li S. Network pharmacology to
explore the anti-inflammatory mechanism of Xuebijing in the treatment
of sepsis. Phytomedicine. 2021 May;85:153543.
- Li R, Guo C, Li Y, Qin Z, Huang W. Therapeutic targets and signaling
mechanisms of vitamin C activity against sepsis: a bioinformatics
study. Brief Bioinform. 2021 May 20;22(3):bbaa079.
- Lu J, Yan J, Yan J, Zhang L, Chen M, Chen Q, Cheng L, Li P. Network
pharmacology based research into the effect and mechanism of Xijiao
Dihuang decoction against sepsis. Biomed Pharmacother. 2020
Feb;122:109777.
- Fu ZH, Zhao LL, Zhou L, Li XC, Zhang XC. [Mechanism and experimental
verification of Dachengqi Decoction in treatment of sepsis based on
network pharmacology]. Zhongguo Zhong Yao Za Zhi. 2021
Oct;46(20):5351-5361. Chinese.
- Song Y, Lin W, Zhu W. Traditional Chinese medicine for treatment of
sepsis and related multi-organ injury. Front Pharmacol. 2023 Jan
19;14:1003658.
- Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer
M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS,
Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll
T, Vincent JL, Angus DC. The Third International Consensus Definitions
for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016 Feb
23;315(8):801-10.
- Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A,
Rubenfeld G, Kahn JM, Shankar-Hari M, Singer M, Deutschman CS, Escobar
GJ, Angus DC. Assessment of Clinical Criteria for Sepsis: For the
Third International Consensus Definitions for Sepsis and Septic Shock
(Sepsis-3). JAMA. 2016 Feb 23;315(8):762-74.
- Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni
L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G,
Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators;
ESICM Trials Group. Epidemiology, Patterns of Care, and Mortality for
Patients With Acute Respiratory Distress Syndrome in Intensive Care
Units in 50 Countries. JAMA. 2016 Feb 23;315(8):788-800.
- Bittencourt-Mernak MI, Pinheiro NM, Santana FP, Guerreiro MP,
Saraiva-Romanholo BM, Grecco SS, Caperuto LC, Felizardo RJ, Câmara NO,
Tibério IF, Martins MA, Lago JH, Prado CM. Prophylactic and
therapeutic treatment with the flavonone sakuranetin ameliorates
LPS-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol.
2017 Feb 1;312(2):L217-L230.
- Margaria JP, Moretta L, Alves-Filho JC, Hirsch E. PI3K Signaling in
Mechanisms and Treatments of Pulmonary Fibrosis Following Sepsis and
Acute Lung Injury. Biomedicines. 2022 Mar 23;10(4):756.
- Yang R, Yang H, Wei J, Li W, Yue F, Song Y, He X, Hu K. Mechanisms
Underlying the Effects of Lianhua Qingwen on Sepsis-Induced Acute Lung
Injury: A Network Pharmacology Approach. Front Pharmacol. 2021 Oct
14;12:717652.
- Peerapornratana S, Manrique-Caballero CL, Gómez H, Kellum JA. Acute
kidney injury from sepsis: current concepts, epidemiology,
pathophysiology, prevention and treatment. Kidney Int. 2019
Nov;96(5):1083-1099.
- Poston JT, Koyner JL. Sepsis associated acute kidney injury. BMJ. 2019
Jan 9;364:k4891.
- Yao T, Zhang L, Fu Y, Yao L, Zhou C, Chen G. Saikosaponin-d Alleviates
Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via
TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition. Mol Cell Biol. 2021
Sep 24;41(10):e0033221.
- Tang JL, Xin M, Zhang LC. Protective effect of Astragalus membranaceus
and Astragaloside IV in sepsis-induced acute kidney injury. Aging
(Albany NY). 2022 Jul 20;14(14):5855-5877.
- Bi CF, Liu J, Yang LS, Zhang JF. Research Progress on the Mechanism of
Sepsis Induced Myocardial Injury. J Inflamm Res. 2022 Jul
26;15:4275-4290.
- Kakihana Y, Ito T, Nakahara M, Yamaguchi K, Yasuda T. Sepsis-induced
myocardial dysfunction: pathophysiology and management. J Intensive
Care. 2016 Mar 23;4:22.
- Walley KR. Sepsis-induced myocardial dysfunction. Curr Opin Crit Care.
2018 Aug;24(4):292-299.
- Wang X, Kong C, Liu P, Zhou B, Geng W, Tang H. Therapeutic Effects of
Retinoic Acid in Lipopolysaccharide-Induced Cardiac Dysfunction:
Network Pharmacology and Experimental Validation. J Inflamm Res. 2022
Aug 30;15:4963-4979.
- Wu J, Wang Z, Xu S, Fu Y, Gao Y, Wu Z, Yu Y, Yuan Y, Zhou L, Li P.
Analysis of the role and mechanism of EGCG in septic cardiomyopathy
based on network pharmacology. PeerJ. 2022 Mar 9;10:e12994.
- Azmi AS. Adopting network pharmacology for cancer drug discovery. Curr
Drug Discov Technol. 2013 Jun;10(2):95-105.
- Poornima P, Kumar JD, Zhao Q, Blunder M, Efferth T. Network
pharmacology of cancer: From understanding of complex interactomes to
the design of multi-target specific therapeutics from nature.
Pharmacol Res. 2016 Sep;111:290-302.
- Gomez-Cadena A, Barreto A, Fioretino S, Jandus C. Immune system
activation by natural products and complex fractions: a network
pharmacology approach in cancer treatment. Cell Stress. 2020 May
18;4(7):154-166.
- Wu C, Huang ZH, Meng ZQ, Fan XT, Lu S, Tan YY, You LM, Huang JQ,
Stalin A, Ye PZ, Wu ZS, Zhang JY, Liu XK, Zhou W, Zhang XM, Wu JR. A
network pharmacology approach to reveal the pharmacological targets
and biological mechanism of compound kushen injection for treating
pancreatic cancer based on WGCNA and in vitro experiment validation.
Chin Med. 2021 Nov 22;16(1):121.
- Wong YH, Lin CL, Chen TS, Chen CA, Jiang PS, Lai YH, Chu L, Li CW,
Chen JJ, Chen BS. Multiple target drug cocktail design for attacking
the core network markers of four cancers using ligand-based and
structure-based virtual screening methods. BMC Med Genomics. 2015;8
Suppl 4(Suppl 4):S4.
- Hansson GK. Inflammation, atherosclerosis, and coronary artery
disease. N Engl J Med. 2005 Apr 21;352(16):1685-95.
- Musunuru K, Hershberger RE, Day SM, Klinedinst NJ, Landstrom AP,
Parikh VN, Prakash S, Semsarian C, Sturm AC; American Heart
Association Council on Genomic and Precision Medicine; Council on
Arteriosclerosis, Thrombosis and Vascular Biology; Council on
Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology.
Genetic Testing for Inherited Cardiovascular Diseases: A Scientific
Statement From the American Heart Association. Circ Genom Precis Med.
2020 Aug;13(4):e000067.
- Van Camp G. Cardiovascular disease prevention. Acta Clin Belg. 2014
Dec;69(6):407-11.
- Shi M, Li B, Yuan Q, Gan X, Ren X, Jiang S, Liu Z. Network
Pharmacology-Based Approach to Investigate the Mechanisms of Mahai
Capsules in the Treatment of Cardiovascular Diseases. Evid Based
Complement Alternat Med. 2020 May 12;2020:9180982.
- Yu T, Zhang YX, Liu XJ, Chen DQ, Wang DD, Zhu GQ, Gao Q. Investigation
of the pharmacological effect and mechanism of mountain-cultivated
ginseng and garden ginseng in cardiovascular diseases based on network
pharmacology and zebrafish experiments. Front Pharmacol. 2022 Sep
1;13:920979.
- Zhang X, Wang D, Ren X, Atanasov AG, Zeng R, Huang L. System
Bioinformatic Approach Through Molecular Docking, Network Pharmacology
and Microarray Data Analysis to Determine the Molecular Mechanism
Underlying the Effects of Rehmanniae Radix Praeparata on
Cardiovascular Diseases. Curr Protein Pept Sci. 2019;20(10):964-975.
- Shalev D, Fields L, Shapiro PA. End-of-Life Care in Individuals With
Serious Mental Illness. Psychosomatics. 2020 Sep-Oct;61(5):428-435.
- Zhang H, Zhang S, Hu M, Chen Y, Wang W, Zhang K, Kuang H, Wang Q. An
integrative metabolomics and network pharmacology method for exploring
the effect and mechanism of Radix Bupleuri and Radix Paeoniae Alba on
anti-depression. J Pharm Biomed Anal. 2020 Sep 10;189:113435.
- Qi Y, Ni S, Heng X, Qu S, Ge P, Zhao X, Yao Z, Guo R, Yang N, Zhang Q,
Zhu H. Uncovering the Potential Mechanisms of Coptis chinensis Franch.
for Serious Mental Illness by Network Pharmacology and
Pharmacology-Based Analysis. Drug Des Devel Ther. 2022 Feb
9;16:325-342.
- Xia QD, Xun Y, Lu JL, Lu YC, Yang YY, Zhou P, Hu J, Li C, Wang SG.
Network pharmacology and molecular docking analyses on Lianhua Qingwen
capsule indicate Akt1 is a potential target to treat and prevent
COVID-19. Cell Prolif. 2020 Dec;53(12):e12949.
- Tao Q, Du J, Li X, Zeng J, Tan B, Xu J, Lin W, Chen XL. Network
pharmacology and molecular docking analysis on molecular targets and
mechanisms of Huashi Baidu formula in the treatment of COVID-19. Drug
Dev Ind Pharm. 2020 Aug;46(8):1345-1353.
- Liu DY, Liu JC, Liang S, Meng XH, Greenbaum J, Xiao HM, Tan LJ, Deng
HW. Drug Repurposing for COVID-19 Treatment by Integrating Network
Pharmacology and Transcriptomics. Pharmaceutics. 2021 Apr
14;13(4):545.