6.1 Cancer
Cancer is a disease caused by the abnormality of a complex biological network. Some drugs targeting a single target or pathway in the past may not achieve the expected effect in the treatment of some malignant tumors [61]. Therefore, using a system network method to find therapeutic drugs has become a reliable method. This strategy helps to identify the specific signal pathways driving tumor-promoting or anti-tumor signals, and improve drug reuse and development[62,63]. Wu[64]et al. Used weighted gene coexpression network analysis (WGCNA) and network pharmacology to explore the potential mechanism of Compound Kushen Injection (CKI) in the treatment of pancreatic cancer (PC). After molecular docking and experimental verification, they finally found that CDK1, Jak1, EGFR, mapk1, and mapk3 were the core genes regulated by CKI in the treatment of PC. Wo [65] et al. Screened 28 important proteins of four kinds of cancer (bladder cancer, colorectal cancer, liver cancer, and lung cancer) through system biology and computer assistance, and found new drug pathways with multiple target effects through systematic evaluation and analysis.