6.2 Cardiovascular disease
The pathogenesis of cardiovascular disease (CVD) is complex and diverse, and it is also one of the diseases with the highest mortality in the world, including atherosclerosis, arrhythmia, hypertension, and aneurysm[66,67,68]. With the development of medical technology, scholars have gradually realized that the pathogenesis of cardiovascular disease is complex and involves multiple targets[69]. At this time, network pharmacology has been a concern for more and more scholars, and occupies an important position in the mechanism research and drug development of cardiovascular disease treatment. Yu[70] et al. Explored the effects of wild ginseng and garden ginseng on cardiovascular diseases by combining metabonomics and network pharmacology, and found that both kinds of ginseng can pass HIF-1 α/ The vascular endothelial growth factor signaling pathway protects the injured internode vessels, and determines the potential mechanism of different metabolites in CVD. Zhang [71] et al. Discovered Rehmannia glutinosa (RRP) as a new potential herbal medicine against cardiovascular disease through network pharmacology, and put forward new opinions on the molecular mechanism of RRP-mediated anti-atherosclerosis (AS).