REFERENCES
1. Watters KF. Tracheostomy in Infants and Children. Respir Care 2017;62(6):799–825.
2. Pérez-Ruiz E, Caro P, Pérez-Frías J, Cols M, Barrio I, Torrent A, García MÁ, Asensio O, Pastor MD, Luna C, et al. Paediatric patients with a tracheostomy: a multicentre epidemiological study. Eur Respir J 2012;40(6):1502–1507.
3. Roberts J, Powell J, Begbie J, Siou G, McLarnon C, Welch A, McKean M, Thomas M, Ebdon A-M, Moss S, et al. Pediatric tracheostomy: A large single-center experience. Laryngoscope 2020;130(5):E375–E380.
4. Hall N, Rousseau N, Hamilton DW, Simpson AJ, Powell S, Brodlie M, Powell J. Impact of COVID-19 on carers of children with tracheostomies. Arch Dis Child 2022;107(3):e23.
5. Özmen S, Özmen ÖA, Ünal ÖF. Pediatric tracheotomies: A 37-year experience in 282 children. Int J Pediatr Otorhinolaryngol 2009;73(7):959–961.
6. Watters K, O’Neill M, Zhu H, Graham RJ, Hall M, Berry J. Two-year mortality, complications, and healthcare use in children with medicaid following tracheostomy. Laryngoscope 2016;126(11):2611–2617.
7. Mahida JB, Asti L, Boss EF, Shah RK, Deans KJ, Minneci PC, Jatana KR. Tracheostomy Placement in Children Younger Than 2 Years: 30-Day Outcomes Using the National Surgical Quality Improvement Program Pediatric. JAMA Otolaryngol Head Neck Surg 2016;142(3):241–246.
8. Shah RK, Stey AM, Jatana KR, Rangel SJ, Boss EF. Identification of opportunities for quality improvement and outcome measurement in pediatric otolaryngology. JAMA Otolaryngol Head Neck Surg 2014;140(11):1019–1026.
9. Thomas AN, McGrath BA. Patient safety incidents associated with airway devices in critical care: a review of reports to the UK National Patient Safety Agency. Anaesthesia 2009;64(4):358–365.
10. Berry JG, Graham DA, Graham RJ, Zhou J, Putney HL, O’Brien JE, Roberson DW, Goldmann DA. Predictors of clinical outcomes and hospital resource use of children after tracheotomy. Pediatrics 2009;124(2):563–572.
11. Zhu H, Das P, Roberson DW, Jang J, Skinner ML, Paine M, Yuan J, Berry J. Hospitalizations in children with preexisting tracheostomy: a national perspective. Laryngoscope 2015;125(2):462–468.
12. Powell J, Keltie K, Sims A, Richardson H, Brodlie M, Powell S. National Cohort Study of Health Care Resource Use After Pediatric Tracheostomy. JAMA Pediatr 2022;176(8):817–819.
13. Meier JD, Valentine KJ, Hagedorn C, Hartling C, Gershan W, Muntz HR, Murphy NA. Emergency department use among children with tracheostomies: Avoidable visits. J Pediatr Rehabil Med 2015;8(2):105–111.
14. Hall N, Rousseau N, Hamilton DW, Simpson AJ, Powell S, Brodlie M, Powell J. Providing care for children with tracheostomies: a qualitative interview study with parents and health professionals. BMJ Open 2023;13(1):e065698.
15. Gipsman A, Prero M, Toltzis P. Tracheobronchitis in children with tracheostomy tubes: Overview of a challenging problem. Pediatric 2022.
16. Tamma PD, Turnbull AE, Milstone AM, Lehmann CU, Sydnor ERM, Cosgrove SE. Ventilator-associated tracheitis in children: does antibiotic duration matter? Clin Infect Dis 2011;52(11):1324–1331.
17. Morrison JM, Hassan A, Kysh L, Dudas RA, Russell CJ. Diagnosis, management, and outcomes of pediatric tracheostomy-associated infections: A scoping review. Pediatr Pulmonol 2022;57(5):1145–1156.
18. Feudtner C, Christakis DA, Connell FA. Pediatric Deaths Attributable to Complex Chronic Conditions: A Population-Based Study of Washington State, 1980–1997. Pediatrics 2000 [accessed 2023 Aug 1];106(Supplement_1):205–209.
19. Sommer MOA, Dantas G, Church GM. Functional characterization of the antibiotic resistance reservoir in the human microflora. Science 2009;325(5944):1128–1131.
20. Apjok G, Számel M, Christodoulou C, Seregi V, Vásárhelyi BM, Stirling T, Eszenyi B, Sári T, Vidovics F, Nagrand E, et al. Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains. Nat Microbiol 2023;8(3):410–423.
21. Wang C-Y, Chen Y-H, Fang C, Zhou M-M, Xu H-M, Jing C-M, Deng H-L, Cai H-J, Jia K, Han S-Z, et al. Antibiotic resistance profiles and multidrug resistance patterns of Streptococcus pneumoniae in pediatrics: A multicenter retrospective study in mainland China. Medicine 2019;98(24):e15942.
22. Antimicrobial resistance. [accessed 2023 Jun 8]. https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance
23. Pozzi M, Pellegrino P, Galbiati S, Granziera M, Locatelli F, Carnovale C, Perrone V, Antoniazzi S, Perrotta C, Strazzer S, et al. Prevalence of respiratory colonisations and related antibiotic resistances among paediatric tracheostomised patients of a long-term rehabilitation centre in Italy. Eur J Clin Microbiol Infect Dis 2015;34(1):169–175.
24. Morrison JM, Hassan A, Kysh L, Dudas RA, Russell CJ. Diagnosis, management, and outcomes of pediatric tracheostomy-associated infections: A scoping review. Pediatr Pulmonol 2022;57(5):1145–1156.
25. Powell J, Powell S, Mather MW, Beck L, Nelson A, Palmowski P, Porter A, Coxhead J, Hedley A, Scott J, et al. Tracheostomy in children is associated with neutrophilic airway inflammation. Thorax 2023 Feb 20.
26. Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ 2021;372:n160.
27. Majmudar P, Sanders DB, Slaven J, Cristea AI. Outpatient Treatment of Lower Respiratory Tract Infections in Children with Tracheostomy - A Single Institution Experience. In: B51. PEDIATRIC SLEEP II. American Thoracic Society; 2020. p. A3685–A3685. (American Thoracic Society International Conference Abstracts).
28. Russell CJ, Mack WJ, Schrager SM, Wu S. Care Variations and Outcomes for Children Hospitalized With Bacterial Tracheostomy-Associated Respiratory Infections. Hosp Pediatr 2017;7(1):16–23.
29. Russell CJ, Mamey MR, Koh JY, Schrager SM, Neely MN, Wu S. Length of Stay and Hospital Revisit After Bacterial Tracheostomy-Associated Respiratory Tract Infection Hospitalizations. Hosp Pediatr 2018;8(2):72–80.
30. Smith CJ, Sierra CM, Robbins J, Cobbina E. Enteral antipseudomonal fluoroquinolones for ventilator-associated tracheobronchitis in children with pre-existing tracheostomy. Pediatr Pulmonol 2022;57(4):1064–1071.
31. Brook I. Treatment of aspiration or tracheostomy-associated pneumonia in neurologically impaired children: effect of antimicrobials effective against anaerobic bacteria. Int J Pediatr Otorhinolaryngol 1996;35(2):171–177.
32. Tan C-Y, Chiu N-C, Lee K-S, Chi H, Huang F-Y, Huang DT-N, Chang L, Kung Y-H, Huang C-Y. Respiratory tract infections in children with tracheostomy. J Microbiol Immunol Infect 2020;53(2):315–320.
33. Atag E, Unal F, Arslan H, Teber BG, Telhan L, Ersu R, Karakoc F, Oktem S. The effect of nebulized antibiotics in children with tracheostomy. Int J Pediatr Otorhinolaryngol 2021;143:110665.
34. Jutras C, Autmizguine J, Chomton M, Marquis C, Nguyen TT-D, Roumeliotis N, Emeriaud G. Inhaled Antibiotics for the Prevention of Respiratory Tract Infections in Children With a Tracheostomy. Front Pediatr 2021;9:633039.
35. Hughes KM, Cristea AI, Tillman EM. Tobramycin Serum Concentrations in Tracheostomy-Dependent Children Receiving Inhaled Tobramycin. Pediatr Allergy Immunol Pulmonol 2020;33(2):92–95.
36. Eckerland M, Bock C, Olivier M, Pichlmaier L, Steindor M, Stehling F. Reducing the frequency of respiratory tract infections in severe neurological disorders by inhaled antibiotics: a retrospective data analysis. ERJ Open Res 2019;5(3).
37. Prinzi AM, Wattier RL, Curtis DJ, Ziniel SI, Fitzgerald A, Pearce K, Parker SK. Impact of Organism Reporting from Endotracheal Aspirate Cultures on Antimicrobial Prescribing Practices in Mechanically Ventilated Pediatric Patients. J Clin Microbiol 2022;60(11):e0093022.
38. Cline JM, Woods CR, Ervin SE, Rubin BK, Kirse DJ. Surveillance tracheal aspirate cultures do not reliably predict bacteria cultured at the time of an acute respiratory infection in children with tracheostomy tubes. Chest 2012;141(3):625–631.
39. Yalamanchi S, Saiman L, Zachariah P. Decision-Making Around Positive Tracheal Aspirate Cultures: The Role of Neutrophil Semiquantification in Antibiotic Prescribing. Pediatr Crit Care Med 2019;20(8):e380–e385.
40. Zampieri FG, Nassar AP Jr, Gusmao-Flores D, Taniguchi LU, Torres A, Ranzani OT. Nebulized antibiotics for ventilator-associated pneumonia: a systematic review and meta-analysis. Crit Care 2015;19(1):150.
41. Smith S, Rowbotham NJ. Inhaled anti-pseudomonal antibiotics for long-term therapy in cystic fibrosis. Cochrane Database Syst Rev 2022;11(11):CD001021.
42. Laska IF, Crichton ML, Shoemark A, Chalmers JD. The efficacy and safety of inhaled antibiotics for the treatment of bronchiectasis in adults: a systematic review and meta-analysis. Lancet Respir Med 2019;7(10):855–869.
43. Kuhn RJ. Formulation of aerosolized therapeutics. Chest 2001;120(3 Suppl):94S–98S.
44. Avelino MAG, Maunsell R, Valera FCP, Lubianca JF, Schweiger C, Miura CS, Chen VG, Manrique D, Oliveira R, Gavazzoni F, et al. First Clinical Consensus and National Recommendations on Tracheostomized Children of the Brazilian Academy of Pediatric Otorhinolaryngology (ABOPe) and Brazilian Society of Pediatrics (SBP)☆,☆☆. Braz J Otorhinolaryngol 2017;83:498–506.
45. Legg J, Allen J-L, Andrew M, Annesley C, Chatwin M, Crawford H, Elverson J, Forton J, Oulton K, Renton K, et al. BTS Clinical Statement on the prevention and management of community-acquired pneumonia in people with learning disability. Thorax 2023;78(Suppl 1):s22–s52.
46. Pérez-Losada M, Graham RJ, Coquillette M, Jafarey A, Castro-Nallar E, Aira M, Hoptay C, Freishtat RJ, Mansbach JM. Tracheal Microbiota in Patients With a Tracheostomy Before, During and After an Acute Respiratory Infection. Pediatr Infect Dis J 2018;37(11):e269–e271.
47. Pérez-Losada M, Graham RJ, Coquillette M, Jafarey A, Castro-Nallar E, Aira M, Freishtat RJ, Mansbach JM. The temporal dynamics of the tracheal microbiome in tracheostomised patients with and without lower respiratory infections. PLoS One 2017;12(8):e0182520.