Figure 1: Effects of TRAM-34 on DADs and DAD-induced trigger activity were induced under isoproterenol/high calcium:
Each panel depicts a train of 10 beats of a basic cycle length (BCL) of 500, 300, 200ms followed by a pause. A: Isoproterenol and high calcium induced prominent DADs and trigger activity in PVs. B: Addition of 5uM TRAM-34 eliminate the DADs and DADs induced trigger activity. C: Wash out TRAM-34, DADs and trigger activity were induced again. D and F: Incidence of DAD-induced triggered activity in different sites of the heart expose to high calcium and isoproterenol alone or in combine with 5uM TRAM-34.
DAD, delayed afterdepolarization; TRAM-34, triarylmethane-34