Figure 1: Effects of TRAM-34 on DADs and DAD-induced trigger
activity were induced under isoproterenol/high calcium:
Each panel depicts a train of 10 beats of a basic cycle length (BCL) of
500, 300, 200ms followed by a pause. A: Isoproterenol and high calcium
induced prominent DADs and trigger activity in PVs. B: Addition of 5uM
TRAM-34 eliminate the DADs and DADs induced trigger activity. C: Wash
out TRAM-34, DADs and trigger activity were induced again. D and F:
Incidence of DAD-induced triggered activity in different sites of the
heart expose to high calcium and isoproterenol alone or in combine with
5uM TRAM-34.
DAD, delayed afterdepolarization; TRAM-34, triarylmethane-34