3.3 Network alteration without change in the overall topology
The scenario where the protein connectivity is altered upon transient
association without much deviation in the backbone conformation are
interesting. This suggests that the signal from the interface to
non-interface residues can be transmitted via small, concerted,
side-chain conformational changes without undergoing any large backbone
conformational changes. The data points corresponding to such cases can
be found on the upper left quadrant of the scatter plot, where the NDS
is high and RMSD is very low. A detailed list of all the cases that fall
into this category can be found in Supplementary Table 3 along with
their computed comparison metrics. Of the 194 cases that show such
variability, few interesting cases have been chosen for detailed studies
below.