Figure
1. Compound 11 treatment reduces AEP activity in injured nerves.
Sciatic nerves were cut and surgically repaired in wild type mice.
Beginning on the third post-injury day, animals were administered either
CP11 or vehicle, orally, once daily. Repaired nerves were harvested and
assayed for AEP activity on the third (3d) or seventh (7d) after the
onset of treatment. A set of intact nerves was assayed similarly for
controls. Mean (+ SEM) AEP activity is scaled to the maximum
activity found in all samples.