Figure 1. Compound 11 treatment reduces AEP activity in injured nerves. Sciatic nerves were cut and surgically repaired in wild type mice. Beginning on the third post-injury day, animals were administered either CP11 or vehicle, orally, once daily. Repaired nerves were harvested and assayed for AEP activity on the third (3d) or seventh (7d) after the onset of treatment. A set of intact nerves was assayed similarly for controls. Mean (+ SEM) AEP activity is scaled to the maximum activity found in all samples.