Figure 2. Treatments with CP11 result in larger restored
neuromuscular responses. A. Outline of experimental scheme. Mice were
treated with CP11 or vehicle daily, five days per week for two weeks,
beginning on the third day following sciatic nerve transection and
repair. After two more weeks, neuromuscular reinnervation was tested. B.
Examples of maximal amplitude M responses (Mmax) recorded four weeks
after sciatic nerve transection and repair from a vehicle-treated (top)
and a CP11-treated (bottom) mouse. C. Mean (+ SEM) amplitudes of
Mmax recorded from tibialis anterior (TA) and lateral gastrocnemius (LG)
in vehicle-treated and CP11-treated mice, either via i.p. injection or
oral gavage, four weeks after sciatic nerve transection and repair.
Significance of differences between CP11-treated and vehicle-treated
mice was evaluated for each muscle using ANOVA and post hoc paired
testing. P values are shown to indicate the significance of differences
in paired comparisons.