Author/Year |
Age/Sex |
Symptoms |
Signs/Laboratory examination |
Disease course |
Endoscopic findings |
Histopathologic findings |
Misdiagnosis |
PCR/VCA-IgM/VCA-IgG/EA/EBV DNA/EBER |
Serum EBV DNA
(copies/ml) |
Medication/Surgery |
Follow-up and
prognosis |
Our case |
49/M |
Abdominal pain |
CRP 38.67 mg/L, CA72-4 10.32 U/ml, UA
446 µmol/L |
3 years |
Multiple ulcers in the colon |
Slight mucosal
changes (crypt branching, twisting and elongation) from the ileocecal
part to the descending colon, focal enhancement, inflammation, obvious
crypt withering and ulcers in the ileocecal region, prominent lymphocyte
infiltration. |
UC |
+/-/+/NT/NT/+/T |
1.75× 10^3 |
Hormone plus
gamma globulin/Emergency right hemicolectomy exploratory laparotomy |
Died 1 month after exploratory laparotomy |
Yangxiao Zhou, 2020 |
50/M |
Abdominal pain, diarrhoea, high fever,
Weight loss |
WBC 13.4 × 109/L,
neutrophil ratio 0.8, Hb 120.0 g/L, PLT 289.0 × 109/L;
ESR 31 mm/1H, CRP 90.2 mg/l, calcitonin
To 0.46 μ g/L and
ferritin > 2000 μ g/L
|
2 months |
Multiple ulcers of
colon, Ileal aphthous ulcer |
acute and chronic inflammation with
lymphoproliferation in the ileocecal mucosa, which was dominated by T
lymphoproliferation and ulcerated |
IBD |
NT/NT/NT/NT/NT/+ |
1.29×10^6 |
Intravenous methylprednisolone, glucocorticoids/NA |
3
months, died of haemorrhagic shock, Gastrointestinal |
|
51/M |
High fever, diarrhoea, abdominal pain,Haematochezia |
NA/procalcitonin 0.07 µg/L |
1 months |
Multiple deep ulcers of colon
and rectum |
Full thickness light moderate chronic inflammation of
colonic mucosa |
IBD |
NT/NT/NT/NT/NT/+ |
4.63×10^4 |
Intravenous
methylprednisolone, glucocorticoids/NA |
Continuous
follow-up |
|
24/M |
Fever, rash, haematochezia |
Splenomegaly, Pelvic small lymph
node shadow |
3 years |
Multiple jejunal ulcer |
Moderate chronic
inflammation of mucosa with lymphangiectasia |
IBD |
NT/NT/NT/NT/NT/+ |
4.34×10^6 |
Intravenous methylprednisolone, glucocorticoids/NA |
loss
to follow-up |
Bo Zhang, 2020 |
39/M |
Abdominal pain, fever, adenopathy, diarrhoea,
haematochezia |
Hb 12 g/L,
inflammatory
indicators
increased,
coagulation
function altered
|
|
Numerous irregular ulcers in the colon |
Lymphatic
follicles in the lamina
propria, crypt abscess in some
glands,
aggregation of atypical lymphoid cells
|
UC |
NT/NT/NT/NT/NT/+ |
<5 × 10^3 |
- |
- |
|
28/M |
Abdominal pain, fever, adenopathy, retrosternal pain,
diarrhoea, splenomegaly |
Hb 92 g/L,
inflammatory
indicators
increased,
coagulation
function altered
|
|
Numerous
shallow and
small
ulcers in
the colon
|
Tissue
granulation, atypical lymphocyte
infiltration
|
IBD |
NT/NT/NT/NT/NT/+ |
3.8 × 10^4 |
- |
- |
|
48/F |
Abdominal pain, fever, adenopathy |
Hb 105
g/L, inflammatory
indicators
increased,
coagulation
function altered
|
|
Numerous
irregular
ulcers
in the colon
|
Granulomatous
tissue and lymphoid
tissue hyperplasia, atypical
lymphocyte
infiltration
|
CD |
NT/NT/NT/NT/NT/+ |
NA |
- |
- |
Dong Xuyang, 2018 |
62/M |
Abdominal pain, haematochezia, high fever,
diarrhoea |
Haemoglobin decreased, RBC decreased, WBC
decreased, thrombocytopenia, coagulation
function altered
|
2 months |
Multiple deep ulcers in the colon |
Acute and chronic
inflammation |
IBD |
-/-/+/+/-/+ |
3.8× 10^3 |
Ganciclovir,
glucocorticoid, imipenem, cilastatin, vancomycin/NA |
2 weeks, septic
shock, death |
|
27/M |
High fever, diarrhoea, haematochezia, abdominal pain |
Haemoglobin decreased, RBC decreased, WBC decreased, thrombocytopenia,
coagulation function altered |
2 months |
Multiple deep ulcers in the
colon |
Multiple ulcerations of the colon with lymphocytic and
plasmacytic infiltration |
CD |
-/-/+/+/+/+ |
9× 10^4 |
Glucocorticoid, intravenous immunoglobulin/emergency right hemicolectomy |
2 weeks, haemorrhagic shock, death |
|
28/M |
High fever, haematochezia, abdominal pain, diarrhoea |
Haemoglobin decreased, RBC decreased, WBC decreased,
thrombocytopenia, coagulation
function altered
|
5 months |
Multiple ulcers in the colon and ileum |
Acute and chronic
inflammation |
CD |
-/-/+/+/+/+ |
5× 10^5 |
Ganciclovir,
glucocorticoids/NA |
6 months, perforation, death |
|
32/F |
Abdominal pain, diarrhoea, high fever, haematochezia |
Haemoglobin decreased, RBC
decreased,coagulation
function altered
|
14 years |
Multiple ulcers in the colon, duodenum and ileum |
Acute and chronic
inflammation, focal lymphocyte accumulation, focal crypt architectural
irregularity |
UC |
-/-/+/+/-/+ |
8.9× 10^4 |
Glucocorticoid/NA |
2.5
months, death |
|
29/M |
Abdominal pain, dyssynergistic defecation, high fever,
haematochezia |
Haemoglobin decreased, RBC
decreased,coagulation
function altered
|
4 years |
Multiple small intestinal ulcers |
Severe stenosis of the small
intestine with perforation, mucosal ulceration with bleeding and
fibrosis, necrosis and granulation tissue seen on the serosal surface,
abscess formation in the mesentery, and chronic inflammation of lymph
nodes |
CD |
-/-/+/±/-/+ |
2.5× 10^5 |
Intravenous immunoglobulin,
methotrexate, CHOEP regimen for 3 months/partial resection of the small
intestine |
13 months, died of haemorrhagic shock |
|
26/F |
High fever, diarrhoea, abdominal pain, haematochezia |
Haemoglobin decreased, RBC
decreased,coagulation
function altered
|
2 years |
Multiple ulcers in the small intestine, duodenum and ileum |
Extensive
ulceration, disorganized crypt architecture, chronic inflammatory cell
infiltration of the intestinal wall, chronic inflammation of
periintestinal lymph nodes |
IBD |
-/+/+/-/-/+ |
4.5× 10^4 |
Glucocorticoids, cefoperazone sodium sulbactam sodium,
vancomycin/duodenectomy and partial jejunectomy |
2 weeks, died of
haemorrhagic shock |
Rongbei Liu, 2018 |
72/M |
Watery stool, intermittent fever
(>39 °C) |
Hepatomegaly, splenomegaly,
lymphadenopathy/increased WBC, PLT, CRP and ESR, OB(+) |
- |
Numerous
shallow and small ulcers in the colon |
Dense lymphocytic infiltrate in
the lamina propria, transmural inflammation, aggregation of lymphocytes |
|
NT/-/+/NT/NT/+ |
2.30 × 10^4 |
Steroids and antibiotics/YES |
Died |
|
21/M |
Watery stool, intermittent fever (>39 °C) |
Hepatomegaly, splenomegaly/increased WBC, PLT, CRP and ESR, OB(+) |
- |
Numerous irregular ulcers in the colon |
Dense lymphocytic infiltrate in
the lamina propria, intraepithelial lymphocytosis, fissuring ulcers,
crypt abnormalities |
|
NT/-/+/NT/NT/+ |
8.84 × 10^6 |
Steroids,
mesalazine, and antibiotics/YES |
Died |
|
50/F |
Watery stool, intermittent fever (>39 °C) |
Hepatomegaly, splenomegaly/increased WBC, PLT, CRP and ESR, OB(+) |
- |
Numerous ulcers in the small intestine |
Intraepithelial lymphocytosis,
crypt abnormalities, intraepithelial lymphocytosis |
|
NT/-/+/NT/NT/+ |
2.55 × 10^6 |
Mesalazine and antibiotics/YES |
Died |
|
50/M |
Bloody stool, intermittent fever (>39 °C) |
Splenomegaly/increased WBC, PLT, CRP and ESR, OB(+) |
- |
Numerous small
ulcers in the colon and small intestine |
Dense lymphocytic infiltrate
in the lamina, transmural inflammation, fissuring ulcers |
|
NT/-/+/NT/NT/+ |
3.01 × 10^4 |
Mesalazine and steroids/YES |
Survived |
|
70/F |
Intermittent fever |
Splenomegaly/increased WBC, PLT, CRP and
ESR, OB(+) |
- |
NA |
Dense lymphocytic infiltrate in the lamina, crypt
abnormalities, transmural inflammation, fissuring ulcers |
|
NT/-/+/NT/NT/+ |
NA |
Mesalazine and antibiotics/YES |
Survived |
|
40/M |
Bloody stool, intermittent fever (>39 °C) |
Splenomegaly, lymphadenopathy/increased WBC, PLT, CRP and ESR, OB(+) |
- |
Numerous irregular ulcers in the colon |
Crypt abnormalities |
|
NT/-/+/NT/NT/+ |
4.40 × 10^4 |
Mesalazine, steroids, and
antibiotics/NO |
Survived |
|
57/M |
Intermittent fever (>39 °C) |
Splenomegaly,
lymphadenopathy/increased WBC, PLT, CRP and ESR, OB(+) |
- |
Numerous
irregular ulcers in the colon |
Dense lymphocytic infiltrate in the
lamina, intraepithelial lymphocytosis, crypt abnormalities |
|
NT/-/+/NT/NT/+ |
8.17 × 10^3 |
Mesalazine and steroids/NO |
Survived |
|
30/M |
Bloody stool, Intermittent fever (>39 °C) |
Lymphadenopathy/increased WBC, PLT, CRP and ESR, OB(+) |
- |
Numerous
irregular ulcers in the colon |
Intraepithelial lymphocytosis |
|
NT/-/+/NT/NT/+ |
7.06 × 10^6 |
Mesalazine, steroids, and
antibiotics/NO |
Survived |
|
12/M |
Intermittent fever (>39 °C |
Lymphadenopathy/increased WBC, PLT, CRP and ESR, OB(+) |
- |
Numerous
irregular ulcers in the colon, a huge irregular ulcer in the ileocecal
junction |
Dense lymphocytic infiltrate in the lamina |
|
NT/-/+/NT/NT/+ |
4.11 × 10^4 |
Mesalazine, steroids, and antibiotics/NO |
Survived |
|
12/M |
Watery stool, Intermittent fever (>39 °C) |
Lymphadenopathy/increased WBC, PLT, CRP and ESR, OB(+) |
- |
Huge
irregular ulcer in the ileocecal junction |
Dense lymphocytic infiltrate
in the lamina |
|
NT/-/+/NT/NT/+ |
NA |
Mesalazine, steroids,
antibiotics, and traditional Chinese medicine/NO |
Survived |
|
34/F |
Bloody stool, intermittent fever (>39 °C) |
Lymphadenopathy/increased WBC, PLT, CRP and ESR, OB(+) |
- |
Numerous
ulcers in the colon |
Intraepithelial lymphocytosis |
|
NT/-/+/NT/NT/+ |
5.71 × 10^5 |
Mesalazine, steroids, and antibiotics/NO |
Survived |
Yu Zhang, 2017 |
55/M |
Abdominal pain, diarrhoea, high fever, bloody
stool |
Mild splenomegaly/increased WBC, CRP, OB(+) |
3 years |
Multiple superficial polymorphic ulcers covered with
pus
Moss all over the terminal ileum and
colon,
resulted in partial luminal stenosis
|
Chronic
active inflammation with a large
amount of
neutrophils and lymphocytes infiltrated
with
a normal tissue structure, partial cryptitis
|
IBD |
+/NT/NT/NT/NT/+ |
NA |
_ |
_ |
Si Wei, 2016 |
55/M |
Recurrent fever with diarrhoea |
Increased WBC |
11 years |
Diffuse patchy ulceration of the mucosa of the transverse,
descending and sigmoid colons |
Oedema of the colorectal mucosa,
lymphocyte and plasma cell infiltration, crypt architectural changes
were not evident, cryptitis and crypt abscesses occasionally seen, ulcer
formation |
IBD |
NA/+ |
NA |
_ |
_ |
Antonio Cuadrado Lav í n, 2008 |
49/M |
Worsening epigastric pain, |
Decreased haemoglobin |
16 days |
Multiple ulcerated lesions and
white-yellow pseudomembranes in the second duodenal portion |
Ulcerated lesions with ulcerated lesions
with
a lymphocytic and polymorphonuclear inflammatory
infiltrate
|
|
+/-/+/NT/+/+ |
NA |
|
|