Fig. 4. Graphical representation of the main metaplastic changes
on glutamatergic mPFC-NAc-Hipp brain areas induced by brief EE
exposure.
A brief EE exposure was able to alter postsynaptic NMDA/AMPA receptor
configurations, through changes in subunit composition of such
receptors, as well as changes in the expression of their main
scaffolding proteins (i.e., SAP102, SAP97). Importantly, the modulation
profile of glutamatergic synapses induced by brief EE exposure was
unique for each brain region investigated (mPFC, NAc, Hipp).
Abbreviations: ↑: increased expression; ↓: decreased expression; -: no
change of expression; GluA2, glutamate AMPA receptor subunit 2; GluN2B,
glutamate NMDA receptor subunit 2B; Hipp, hippocampus; mPFC, medial
prefrontal cortex; NAc, nucleus accumbens; SAP102, synapse-associated
protein 102; SAP97, synapse-associated protein 97.