Conclusion

Our study concludes that variants of the AKAP11 gene have a strong effect on the diagnosis of bipolar disorder and a moderate effect on the diagnosis of schizophrenia. Furthermore, our novel processes for variant classification based on the likelihood of diagnosis and comparison against nationwide data can offer future direction in identifying the genetic predisposition of certain vulnerable demographics to SCZ and BPD. Further research should be conducted to validate these observed higher probabilities of AKAP11 variants in the diagnosis of both schizophrenia and bipolar I.