Conclusion
Our study concludes that variants of the AKAP11 gene have a
strong effect on the diagnosis of bipolar disorder and a moderate effect
on the diagnosis of schizophrenia. Furthermore, our novel processes for
variant classification based on the likelihood of diagnosis and
comparison against nationwide data can offer future direction in
identifying the genetic predisposition of certain vulnerable
demographics to SCZ and BPD. Further research should be conducted to
validate these observed higher probabilities of AKAP11 variants
in the diagnosis of both schizophrenia and bipolar I.