Statistical analysis
All the data analyses were conducted by IBM SPSS statistics (Version 25.0, IBM, Armonk, NY, USA) and GraphPad Prism 8 (GraphPad Software, Inc., La Jolla, CA, USA) software. The data were first performed with the normality distribution. Student’s t-test was used for variables in a normal distribution, otherwise, the Mann-Whitney test was used. Linear regression and Pearson’s correlation were applied to explore the correlation analysis. Ap -value < 0.05 was defined as statistically significant.