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\begin{document}

\title{Temporal trends of cancer incidence rates for the most frequent cancer
sites in Cyprus during 2004-2017}



\author[1]{Anastasia  Spartiati}%
\author[2]{Anna  Demetriou}%
\author[2]{Vasos  Scoutellas}%
\author[1]{Costas  Christophi}%
\author[1]{Konstantinos C. C. Makris}%
\affil[1]{Cyprus University of Technology}%
\affil[2]{Government of the Republic of Cyprus Ministry of Health}%


\vspace{-1em}



  
  \date{May 27, 2024}


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\begin{abstract}
Cancer is one of the leading causes of morbidity and mortality,
worldwide. Little information is available for the temporal trends of
cancer in the Mediterranean region, including Cyprus. We aimed to
analyze cancer incidence trends overall and by sex for the period
2004-2017 regarding the five most common cancer sites for the population
of Cyprus. Data were obtained from the nationwide cancer registry
dataset that included 27,017 total cancer cases in Cyprus (2004-2017).
We estimated the crude, sex-, and age-specific, as well as
age-standardized (ASR) cancer incidence rates and we analyzed the time
trends of ASR using the joinpoint regression program. For the general
population (0-85+ years of age), the most common cancer sites in
descending order, were breast, prostate, lung, colorectal, and thyroid
cancer. During the study period, breast and thyroid cancer ASR presented
a significantly increasing temporal trend. Lung cancer ASRs seemed to
stabilize (no increase or decrease) during the more recent years (2009
onwards) for both sexes; a similar pattern was observed for colorectal
cancer in males. The ASRs of prostate cancer in men were in steady
decline from 2012 onwards and the same was observed for the female ASRs
of colorectal cancer from 2007 onwards. The colorectal cancer ASR
temporal patterns overall, during the whole study period appeared
unchanged. This temporal analysis would feed into cancer surveillance
and control programs that focus on prevention, early detection, and
treatment, particularly for cancer sites of higher mortality rates or
those with temporally increasing trends.%
\end{abstract}%



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\textbf{Hosted file}

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\textbf{Hosted file}

\verb`Table_1.docx`  available at \url{https://authorea.com/users/642131/articles/656084-temporal-trends-of-cancer-incidence-rates-for-the-most-frequent-cancer-sites-in-cyprus-during-2004-2017}

\textbf{Hosted file}

\verb`Figure 1.docx`  available at \url{https://authorea.com/users/642131/articles/656084-temporal-trends-of-cancer-incidence-rates-for-the-most-frequent-cancer-sites-in-cyprus-during-2004-2017}

\textbf{Hosted file}

\verb`Figure 2.docx`  available at \url{https://authorea.com/users/642131/articles/656084-temporal-trends-of-cancer-incidence-rates-for-the-most-frequent-cancer-sites-in-cyprus-during-2004-2017}

\textbf{Hosted file}

\verb`Figure 3.docx`  available at \url{https://authorea.com/users/642131/articles/656084-temporal-trends-of-cancer-incidence-rates-for-the-most-frequent-cancer-sites-in-cyprus-during-2004-2017}

\textbf{Hosted file}

\verb`Figure 4.docx`  available at \url{https://authorea.com/users/642131/articles/656084-temporal-trends-of-cancer-incidence-rates-for-the-most-frequent-cancer-sites-in-cyprus-during-2004-2017}

\textbf{Hosted file}

\verb`Figure 5.docx`  available at \url{https://authorea.com/users/642131/articles/656084-temporal-trends-of-cancer-incidence-rates-for-the-most-frequent-cancer-sites-in-cyprus-during-2004-2017}

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